Predictors of mortality and mortality from cardiac causes in the Bypass Angioplasty Revascularization Investigation (BARI) randomized trial and registry

Maria Mori Brooks, Robert H. Jones, Richard G. Bach, Bernard R. Chaitman, Morton J. Kern, Thomas A. Orszulak, Dean Follmann, George Sopko, Eugene H. Blackstone, Robert M. Califf

Research output: Contribution to journalArticlepeer-review

120 Scopus citations

Abstract

Background - The impact of percutaneous transluminal coronary angioplasty (PTCA) and coronary artery bypass grafting (CABG) on long-term mortality rates in the presence of various demographic, clinical, and angiographic factors is uncertain in the population of patients suitable for both procedures. Methods and Results - In the Bypass Angioplasty Revascularization Investigation (BARI) randomized trial and registry, 3610 patients who were eligible to receive PTCA and CABG were revascularized between 1989 and 1992. Multivariate Cox models were used to identify factors associated with 5-year mortality and cardiac mortality, with particular attention to factors that interact with treatment. Diabetic patients receiving insulin had higher mortality and cardiac mortality rates with PTCA compared with CABG (relative risk [RR] 1.78 and 2.63, respectively, P < 0.001), and patients with ST elevation had higher cardiac mortality-tares with CABG than with PTCA (RR 4.08, P < 0.001). Factors most strongly associated with high overall mortality rates were insulin-treated diabetes, congestive heart failure, kidney failure, and older age. Black race was also associated with higher mortality rates (RR 1.49, P = 0.019). Conclusions - A set of variables was identified that could be used to help select a revascularization procedure and to evaluate risk of long-term mortality in the population of patients considering revascularization.

Original languageEnglish
Pages (from-to)2682-2689
Number of pages8
JournalCirculation
Volume101
Issue number23
DOIs
StatePublished - Jun 13 2000

Keywords

  • Angioplasty
  • Bypass
  • Diabetes mellitus
  • Grafting
  • Mortality
  • Trials

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