Predictive value of CD4+ and CD8+ lymphocyte counts for cytomegalovirus retinitis in AIDS patients

S. Okinami, T. Margolis

Research output: Contribution to journalArticle

Abstract

We reviewed the clinical records of 52 patients with AIDS who showed CD4+ lymphocyte counts of less than 50 cells per mm3. All the patients were seen at the San Francisco General Hospital. Cytomegalovirus retinitis developed in 30 patients within 8 weeks after lymphocyte subset analysis. There was no difference in CD8+ counts between patients with and without retinitis. In 27 patients with retinitis, CD8+ count was significantly lower in 14 patients with zone 1 retinal involvement than in 13 without, as CD8+ lymphocyte count was less than 220 per mm3 in 64% of patients with zone 1 involvement and in 15% of patients without. These findings indicate that CD8+ lymphocyte depletion and decreased CD4+ count may be a predictor of zone 1 cytomegalovirus retinitis. We recommend more frequent funduscopic control of AIDS patients with CD4+ lymphocyte counts of less than 50 per mm3 and CD8+ less than 200 per mm3.

Original languageEnglish
Pages (from-to)49-52
Number of pages4
JournalJapanese Journal of Clinical Ophthalmology
Volume50
Issue number1
StatePublished - Jan 1 1996
Externally publishedYes

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