Predictive and prognostic genetic markers in colorectal cancer

Sean C. Glasgow; Matthew G. Mutch

doi:10.1053/j.scrs.2005.02.002

Predictive and prognostic genetic markers in colorectal cancer

Research output: Contribution to journal › Article › peer-review

Abstract

TNM staging remains the most widely applied and clinically useful prognostic marker for colorectal cancer. However, on-going clinical investigations of genes involved in carcinogenesis, profiling of metabolic pathways to determine a tumor's response to chemotherapy, and the evolution of new technology for the simultaneous evaluation of thousands of potential genetic markers promise to improve our ability as surgeons to provide accurate prognoses for individual patients. We review well-known prognostic and predictive genetic markers in colorectal cancer, with emphasis on the use of genomics for determining patient outcome following surgical resection.

Original language	English
Pages (from-to)	163-170
Number of pages	8
Journal	Seminars in Colon and Rectal Surgery
Volume	15
Issue number	3
DOIs	https://doi.org/10.1053/j.scrs.2005.02.002
State	Published - Sep 2004

Keywords

Colorectal cancer
EGFR
Genomics
Markers
Oncogenes
Pharmacogenetics
Prognosis
Tumor suppressor genes
VEGF

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10.1053/j.scrs.2005.02.002

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KW - Colorectal cancer

KW - EGFR

KW - Genomics

KW - Markers

KW - Oncogenes

KW - Pharmacogenetics

KW - Prognosis

KW - Tumor suppressor genes

KW - VEGF

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Predictive and prognostic genetic markers in colorectal cancer

Abstract

Keywords

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