TY - GEN
T1 - Prediction of Treatment Efficacy by Blood Flow Responses to PDT in RIF Tumors
AU - Yu, G.
AU - Durduran, T.
AU - Zhou, C.
AU - Putt, M.
AU - Yodh, A. G.
AU - Busch, T. M.
N1 - Publisher Copyright:
© 2004 Optical Society of America
PY - 2004
Y1 - 2004
N2 - A diffuse correlation spectroscopy (DCS) is used to non-invasively measure in vivo blood flow responses to PDT in mice bearing radiation-induced fibrosarcoma (RIF) tumors. The treatment efficacy, as measured by the tumor regrowth time, significantly correlates with the acute flow reduction rate during PDT, as well as with flow reduction 3 hours after PDT. We surmise from this data that rapid vascular occlusion during PDT shuts off the tissue oxygen supply which in turn reduces PDT efficacy, and greater reduction of blood flow at 3 hours after PDT demonstrates more vascular damage which correlates good treatment efficacy.
AB - A diffuse correlation spectroscopy (DCS) is used to non-invasively measure in vivo blood flow responses to PDT in mice bearing radiation-induced fibrosarcoma (RIF) tumors. The treatment efficacy, as measured by the tumor regrowth time, significantly correlates with the acute flow reduction rate during PDT, as well as with flow reduction 3 hours after PDT. We surmise from this data that rapid vascular occlusion during PDT shuts off the tissue oxygen supply which in turn reduces PDT efficacy, and greater reduction of blood flow at 3 hours after PDT demonstrates more vascular damage which correlates good treatment efficacy.
UR - http://www.scopus.com/inward/record.url?scp=85134596310&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85134596310
T3 - Optics InfoBase Conference Papers
BT - Biomedical Topical Meeting, BIOMED 2004
PB - Optica Publishing Group (formerly OSA)
T2 - Biomedical Topical Meeting, BIOMED 2004
Y2 - 14 April 2004 through 17 April 2004
ER -