Prediction of Treatment Efficacy by Blood Flow Responses to PDT in RIF Tumors

G. Yu, T. Durduran, C. Zhou, M. Putt, A. G. Yodh, T. M. Busch

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


A diffuse correlation spectroscopy (DCS) is used to non-invasively measure in vivo blood flow responses to PDT in mice bearing radiation-induced fibrosarcoma (RIF) tumors. The treatment efficacy, as measured by the tumor regrowth time, significantly correlates with the acute flow reduction rate during PDT, as well as with flow reduction 3 hours after PDT. We surmise from this data that rapid vascular occlusion during PDT shuts off the tissue oxygen supply which in turn reduces PDT efficacy, and greater reduction of blood flow at 3 hours after PDT demonstrates more vascular damage which correlates good treatment efficacy.

Original languageEnglish
Title of host publicationBiomedical Topical Meeting, BIOMED 2004
PublisherOptica Publishing Group (formerly OSA)
ISBN (Electronic)1557527695
StatePublished - 2004
EventBiomedical Topical Meeting, BIOMED 2004 - Miami Beach, United States
Duration: Apr 14 2004Apr 17 2004

Publication series

NameOptics InfoBase Conference Papers
ISSN (Electronic)2162-2701


ConferenceBiomedical Topical Meeting, BIOMED 2004
Country/TerritoryUnited States
CityMiami Beach


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