Prediction of Speech, Swallowing, and Quality of Life in Oral Cavity Cancer Patients: A Pilot Study

Mustafa G. Bulbul, Michael Wu, Derrick Lin, Kevin Emerick, Daniel Deschler, Jeremy Richmon, Tessa Goldsmith, Joseph Zenga, Sidharth V. Puram, Mark A. Varvares

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives/Hypothesis: To investigate the impact of specific treatment-related variables on functional and quality of life outcomes in oral cavity cancer (OCC) patients. Study Design: Retrospective Cohort. Methods: Patients with primary OCC at least 6 months after resection and adjuvant therapy were included. Patients completed surveys including the Speech Handicap Index (SHI), M.D. Anderson Dysphagia Inventory (MDADI), and Functional Assessment of Cancer Therapy-Head and Neck (FACT-HN). Performance Status Scale (PSS) and tongue mobility scale were completed to allow provider-rated assessment of speech and tongue mobility, respectively. Additional details regarding treatment were also collected. These data were used to generate a predictive model using linear regression. Results: Fifty-three patients with oral tongue and/or floor of mouth (FOM) resection were included in our study. In multivariable analysis, greater postoperative tongue range of motion (ROM) and time since treatment improved SHI. Flap reconstruction and greater postoperative tongue ROM increased MDADI and PSS (eating and speech). A larger volume of resected tissue was inversely correlated with PSS (diet and speech). Tumor site was an important predictor of PSS (all sections). There were no statistically significant predictors of FACT-HN. Conclusions: In this pilot study, we propose a battery of tools to assess function in OCC patients treated with surgery. Using the battery of tools we propose, our results show that a surgical endpoint that preserves tongue mobility and employs flap reconstruction resulted in better outcomes, whereas those with greater volume of tissue resected and FOM involvement resulted in poorer outcomes. Larger prospective studies are needed to validate our findings. Level of Evidence: 3 Laryngoscope, 131:2497–2504, 2021.

Original languageEnglish
Pages (from-to)2497-2504
Number of pages8
JournalLaryngoscope
Volume131
Issue number11
DOIs
StatePublished - Nov 2021

Keywords

  • Oral cancer
  • patient reported outcomes
  • quality of life
  • reconstruction

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