TY - JOUR
T1 - Predicting full-length transcripts
AU - Brent, Michael R.
PY - 2002/7/1
Y1 - 2002/7/1
N2 - Accurate prediction of the complete structures of protein-coding genes, including 5′-untranslated regions, is crucial for full interpretation of genome sequence. A new report describes the statistical properties of the first exons of genes, and presents a novel statistical method for predicting their boundaries. First exons, which are partially or completely non-coding, have been relatively neglected by gene-finding algorithms. When integrated with other genome annotation tools, this new method will improve the technology of automated genome interpretation.
AB - Accurate prediction of the complete structures of protein-coding genes, including 5′-untranslated regions, is crucial for full interpretation of genome sequence. A new report describes the statistical properties of the first exons of genes, and presents a novel statistical method for predicting their boundaries. First exons, which are partially or completely non-coding, have been relatively neglected by gene-finding algorithms. When integrated with other genome annotation tools, this new method will improve the technology of automated genome interpretation.
UR - http://www.scopus.com/inward/record.url?scp=0036643974&partnerID=8YFLogxK
U2 - 10.1016/S0167-7799(02)01976-5
DO - 10.1016/S0167-7799(02)01976-5
M3 - Review article
C2 - 12062962
AN - SCOPUS:0036643974
SN - 0167-7799
VL - 20
SP - 273
EP - 275
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 7
ER -