Abstract

This multi-institutional, descriptive study of 19 children with neurofibromatosis 1 examines the link between optic pathway gliomas (OPGs) and central precocious puberty (CPP). We report that CPP can arise without OPG chiasmal involvement and that prior OPG chemotherapy does not prevent the development of CPP.

Original languageEnglish
Article number114440
JournalJournal of Pediatrics
Volume278
DOIs
StatePublished - Mar 2025

Keywords

  • NF1
  • neurofibromatosis
  • optic pathway glioma
  • precocious puberty

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