Keyphrases
Rapamycin
100%
Xenograft
100%
Peripheral Nerve Sheath
100%
In Vivo Evaluation
100%
Malignant Peripheral Nerve Sheath Tumor (MPNST)
100%
Neurofibromatosis Type I
87%
Neurofibromatosis Type 1 (NF-1)
87%
Mammalian Target of Rapamycin (mTOR)
25%
Neurofibromin
25%
Mammalian Target of Rapamycin Pathway
25%
Targeted Therapy
12%
Gene Products
12%
Negatively Regulate
12%
Tumor Cell Lines
12%
Malignant Tumor
12%
SCID Mice
12%
Conventional Chemotherapy
12%
Therapeutic Potential
12%
Tumor Angiogenesis
12%
Tumor Proliferation
12%
Poor Survival
12%
Tumor Patients
12%
MTOR Inhibitor
12%
Pathway Activation
12%
Cyclin D1 (CCND1)
12%
Protein Kinase B
12%
Systemic Metastasis
12%
Tumor Explant
12%
Akt Activation
12%
Therapeutic Limitations
12%
Systemic Toxicity
12%
Protein Kinase B/Akt
12%
Tumor Apoptosis
12%
AKT/mammalian Target of Rapamycin
12%
Medicine and Dentistry
Neurofibromatosis Type I
100%
Xenograft
100%
Rapamycin
100%
Nerve Sheath
100%
Peripheral Nerve
100%
Malignant Peripheral Nerve Sheath Tumor
71%
Mechanistic Target of Rapamycin
57%
Protein Kinase B
42%
Malignant Neoplasm
14%
Neoplasm
14%
Phosphoinositide 3-Kinase
14%
Metastatic Carcinoma
14%
Targeted Therapy
14%
Angiogenesis
14%
SCID Mouse
14%
Programmed Cell Death
14%
Gene Product
14%
Vasculotropin
14%
Tumor Progression
14%
Mammalian Target of Rapamycin Inhibitor
14%
Malignant Peripheral Nerve Sheath Tumor Cell Line
14%
Pharmacology, Toxicology and Pharmaceutical Science
Neurofibromatosis Type 1
100%
Rapamycin
100%
Malignant Peripheral Nerve Sheath Tumor
85%
Mammalian Target of Rapamycin
57%
Protein Kinase B
42%
Neurofibromin
28%
Neoplasm
14%
Tumor Growth
14%
Malignant Neoplasm
14%
Phosphatidylinositol 3 Kinase
14%
Chemotherapy
14%
Vasculotropin
14%
Mammalian Target of Rapamycin Inhibitor
14%
NOD SCID Mouse
14%
Biochemistry, Genetics and Molecular Biology
Explant
100%
Mechanistic Target of Rapamycin
100%
Protein Kinase B
60%
Tumor Progression
20%
Gene Product
20%
Phosphoinositide 3-Kinase
20%
Angiogenesis
20%
Vascular Endothelial Growth Factor
20%
NOD SCID Mouse
20%
Programmed Cell Death
20%