Preclinical evaluation of severely defective manganese-based nanocrystal as a liver-specific contrast media for MR imaging: Comparison with Gd-EOB-DTPA and MnDPDP

Yu Zhang, Xiao Ping Xiao, Ting Shu, Jing Cai, Xin Lan Xiao, Yan Shu Li, Zhong Wei Zhang, Qun Tang

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Abstract

Manganese-based (chemically formulated of KMnF3) nanocrystal was evaluated as a liver-specific contrast agent for MR imaging and its imaging performance was also compared with those of two commercial hepatobiliary contrast media (Gd-EOB-DTPA and MnDPDP). KMnF3 nanocrystal was post-treated using a plasma technique to cause severe defects, leading to appropriate water dispersibility and high relaxivity. Severely defective KMnF3 nanocrystal (SD-KMnF3) has characteristic high tolerance, as evidenced by cytotoxicity on the macrophage cell, and acute and subchronic toxicity on the healthy mouse. SD-KMnF3 showed better hepatic MR imaging as the T 1 relaxation time of the liver decreased to only 17% of the control group, compared to 22% of the control group for Gd-EOB-DTPA (P < 0.01) and 42% of the control group for MnDPDP (P < 0.001). As applied to MR imaging of the allograft orthotopic model of liver cancer, statistical studies demonstrated that SD-KMnF3 significantly improved the tumor's contrast-to-noise ratio, compared with Gd-EOB-DTPA (P < 0.01) and MnDPDP (P < 0.01) by spin-echo pulse sequence, and even better performance (P < 0.001) by gradient-echo sequence. Our findings indicate that SD-KMnF3 could serve as a hepatic contrast agent for imaging liver cancer such as hepatocarcinoma or metastatic lesions.

Original languageEnglish
Article number225101
JournalNanotechnology
Volume29
Issue number22
DOIs
StatePublished - Apr 4 2018

Keywords

  • MRI
  • hepatic contrast agent
  • manganese-based nanocrystal
  • orthotopic model

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