TY - JOUR
T1 - Precision neuromodulation
T2 - Promises and challenges of spinal stimulation for multi-modal rehabilitation
AU - Bandres, Maria F.
AU - Gomes, Jefferson L.
AU - Moreno Romero, Gerson N.
AU - Twyman, Avery R.
AU - McPherson, Jacob Graves
N1 - Publisher Copyright:
2023 Bandres, Gomes, Moreno Romero, Twyman and McPherson.
PY - 2023
Y1 - 2023
N2 - Spinal cord injury results in multiple, simultaneous sensorimotor deficits. These include, but are not limited to, full or partial paralysis of muscles below the lesion, muscle spasms, spasticity, and neuropathic pain. Bowel, bladder, and sexual dysfunction are also prevalent. Yet, the majority of emerging spinal stimulation-based therapies focus on a single issue: locomotor rehabilitation. Despite the enormous potential of these translational advances to transform the lives of people living with spinal cord injury, meaningful recovery in other domains deemed critical priorities remains lacking. Here, we highlight the importance of considering the diverse patterns of neural transmission that underlie clinically similar presentations when developing spinal stimulation-based therapies. We also motivate advancement of multi-modal rehabilitation paradigms, which leverage the dense interconnectivity of sensorimotor spinal networks and the unique ability of electrical stimulation to modulate these networks to facilitate and guide simultaneous rehabilitation across domains.
AB - Spinal cord injury results in multiple, simultaneous sensorimotor deficits. These include, but are not limited to, full or partial paralysis of muscles below the lesion, muscle spasms, spasticity, and neuropathic pain. Bowel, bladder, and sexual dysfunction are also prevalent. Yet, the majority of emerging spinal stimulation-based therapies focus on a single issue: locomotor rehabilitation. Despite the enormous potential of these translational advances to transform the lives of people living with spinal cord injury, meaningful recovery in other domains deemed critical priorities remains lacking. Here, we highlight the importance of considering the diverse patterns of neural transmission that underlie clinically similar presentations when developing spinal stimulation-based therapies. We also motivate advancement of multi-modal rehabilitation paradigms, which leverage the dense interconnectivity of sensorimotor spinal networks and the unique ability of electrical stimulation to modulate these networks to facilitate and guide simultaneous rehabilitation across domains.
KW - locomotion
KW - multimodal rehabilitation
KW - neuromodualtion
KW - pain
KW - rehabiliatation
KW - spinal cord injury
KW - spinal stimulation
UR - http://www.scopus.com/inward/record.url?scp=85174890001&partnerID=8YFLogxK
U2 - 10.3389/fresc.2023.1135593
DO - 10.3389/fresc.2023.1135593
M3 - Article
C2 - 37152244
AN - SCOPUS:85174890001
SN - 2673-6861
VL - 4
JO - Frontiers in Rehabilitation Sciences
JF - Frontiers in Rehabilitation Sciences
M1 - 1135593
ER -