TY - JOUR
T1 - Precision Medicine in Pancreatic Disease-Knowledge Gaps and Research Opportunities
T2 - Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop
AU - Lowe, Mark E.
AU - Andersen, Dana K.
AU - Caprioli, Richard M.
AU - Choudhary, Jyoti
AU - Cruz-Monserrate, Zobeida
AU - Dasyam, Anil K.
AU - Forsmark, Christopher E.
AU - Gorelick, Fred S.
AU - Gray, Joe W.
AU - Haupt, Mark
AU - Kelly, Kimberly A.
AU - Olive, Kenneth P.
AU - Plevritis, Sylvia K.
AU - Rappaport, Noa
AU - Roth, Holger R.
AU - Steen, Hanno
AU - Swamidass, S. Joshua
AU - Tirkes, Temel
AU - Uc, Aliye
AU - Veselkov, Kirill
AU - Whitcomb, David C.
AU - Habtezion, Aida
N1 - Publisher Copyright:
© 2019 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - A workshop on research gaps and opportunities for Precision Medicine in Pancreatic Disease was sponsored by the National Institute of Diabetes and Digestive Kidney Diseases on July 24, 2019, in Pittsburgh. The workshop included an overview lecture on precision medicine in cancer and 4 sessions: (1) general considerations for the application of bioinformatics and artificial intelligence; (2) omics, the combination of risk factors and biomarkers; (3) precision imaging; and (4) gaps, barriers, and needs to move from precision to personalized medicine for pancreatic disease. Current precision medicine approaches and tools were reviewed, and participants identified knowledge gaps and research needs that hinder bringing precision medicine to pancreatic diseases. Most critical were (a) multicenter efforts to collect large-scale patient data sets from multiple data streams in the context of environmental and social factors; (b) new information systems that can collect, annotate, and quantify data to inform disease mechanisms; (c) novel prospective clinical trial designs to test and improve therapies; and (d) a framework for measuring and assessing the value of proposed approaches to the health care system. With these advances, precision medicine can identify patients early in the course of their pancreatic disease and prevent progression to chronic or fatal illness.
AB - A workshop on research gaps and opportunities for Precision Medicine in Pancreatic Disease was sponsored by the National Institute of Diabetes and Digestive Kidney Diseases on July 24, 2019, in Pittsburgh. The workshop included an overview lecture on precision medicine in cancer and 4 sessions: (1) general considerations for the application of bioinformatics and artificial intelligence; (2) omics, the combination of risk factors and biomarkers; (3) precision imaging; and (4) gaps, barriers, and needs to move from precision to personalized medicine for pancreatic disease. Current precision medicine approaches and tools were reviewed, and participants identified knowledge gaps and research needs that hinder bringing precision medicine to pancreatic diseases. Most critical were (a) multicenter efforts to collect large-scale patient data sets from multiple data streams in the context of environmental and social factors; (b) new information systems that can collect, annotate, and quantify data to inform disease mechanisms; (c) novel prospective clinical trial designs to test and improve therapies; and (d) a framework for measuring and assessing the value of proposed approaches to the health care system. With these advances, precision medicine can identify patients early in the course of their pancreatic disease and prevent progression to chronic or fatal illness.
KW - chronic pancreatitis
KW - consensus workshop
KW - pancreatic cancer
KW - personalized medicine
UR - http://www.scopus.com/inward/record.url?scp=85074550484&partnerID=8YFLogxK
U2 - 10.1097/MPA.0000000000001412
DO - 10.1097/MPA.0000000000001412
M3 - Article
C2 - 31688587
AN - SCOPUS:85074550484
SN - 0885-3177
VL - 48
SP - 1250
EP - 1258
JO - Pancreas
JF - Pancreas
IS - 10
ER -