Precise Tuning of Cortical Contractility Regulates Cell Shape during Cytokinesis

Nilay Taneja, Matthew R. Bersi, Sophie M. Baillargeon, Aidan M. Fenix, James A. Cooper, Ryoma Ohi, Vivian Gama, W. David Merryman, Dylan T. Burnette

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Taneja et al. describe distinct roles for the two myosin-II paralogs in regulating actin cortex mechanics during cell division. Myosin-IIA generates cortex tension, while myosin-IIB maintains cortical stability. Optimal levels of the two paralogs within hetero-filaments at the cortex are required for shape stability and cytokinetic fidelity during cell division.

Original languageEnglish
Article number107477
JournalCell Reports
Issue number1
StatePublished - Apr 7 2020


  • actin cortex
  • binucleation
  • bleb
  • cell division
  • cortex tension
  • cytokinesis
  • hydrostatic pressure
  • myosin IIA
  • myosin IIB
  • spindle


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