TY - JOUR
T1 - Precise Topology of Adjacent Domain-General and Sensory-Biased Regions in the Human Brain
AU - Assem, Moataz
AU - Shashidhara, Sneha
AU - Glasser, Matthew F.
AU - Duncan, John
N1 - Publisher Copyright:
© 2021 The Author(s) 2021.
PY - 2022/6/15
Y1 - 2022/6/15
N2 - Recent functional MRI studies identified sensory-biased regions across much of the association cortices and cerebellum. However, their anatomical relationship to multiple-demand (MD) regions, characterized as domain-general due to their coactivation during multiple cognitive demands, remains unclear. For a better anatomical delineation, we used multimodal MRI techniques of the Human Connectome Project to scan subjects performing visual and auditory versions of a working memory (WM) task. The contrast between hard and easy WM showed strong domain generality, with essentially identical patterns of cortical, subcortical, and cerebellar MD activity for visual and auditory materials. In contrast, modality preferences were shown by contrasting easy WM with baseline; most MD regions showed visual preference while immediately adjacent to cortical MD regions, there were interleaved regions of both visual and auditory preference. The results may exemplify a general motif whereby domain-specific regions feed information into and out of an adjacent, integrative MD core.
AB - Recent functional MRI studies identified sensory-biased regions across much of the association cortices and cerebellum. However, their anatomical relationship to multiple-demand (MD) regions, characterized as domain-general due to their coactivation during multiple cognitive demands, remains unclear. For a better anatomical delineation, we used multimodal MRI techniques of the Human Connectome Project to scan subjects performing visual and auditory versions of a working memory (WM) task. The contrast between hard and easy WM showed strong domain generality, with essentially identical patterns of cortical, subcortical, and cerebellar MD activity for visual and auditory materials. In contrast, modality preferences were shown by contrasting easy WM with baseline; most MD regions showed visual preference while immediately adjacent to cortical MD regions, there were interleaved regions of both visual and auditory preference. The results may exemplify a general motif whereby domain-specific regions feed information into and out of an adjacent, integrative MD core.
KW - auditory working memory
KW - domain-general
KW - multiple-demand
KW - sensory-biased
KW - visual working memory
UR - http://www.scopus.com/inward/record.url?scp=85132452290&partnerID=8YFLogxK
U2 - 10.1093/cercor/bhab362
DO - 10.1093/cercor/bhab362
M3 - Article
C2 - 34628494
AN - SCOPUS:85132452290
SN - 1047-3211
VL - 32
SP - 2521
EP - 2537
JO - Cerebral Cortex
JF - Cerebral Cortex
IS - 12
ER -