TY - JOUR
T1 - Precipitous deterioration of motor function, cognition, and behavior
AU - Fernandez-Fournier, Mireya
AU - Perry, David C.
AU - Tartaglia, Maria Carmela
AU - DeMay, Mary
AU - Boxer, Adam
AU - Coppola, Giovanni
AU - Christine, Chadwick W.
AU - Huang, Eric J.
AU - Seeley, William W.
AU - Miller, Bruce L.
AU - DeArmond, Steven J.
AU - Grinberg, Lea T.
AU - Geschwind, Michael D.
N1 - Publisher Copyright:
© 2017 American Medical Association. All rights reserved.
PY - 2017/5
Y1 - 2017/5
N2 - A 72-year-old woman developed new-onset depression, sustained an unexplained fall, and started walking cautiously. After 1 year, her depression resolved but she developed a dry cough. One year later, she experienced a more rapid decline in her gait with parkinsonism, visual difficulties with restricted vertical gaze, slowed horizontal and vertical saccades, dysphagia, apathy, and progressive cognitive decline, which led to her death 2 years later. The differential diagnosis, neuroimaging, and pathological findings are discussed, as well as their public health implications.
AB - A 72-year-old woman developed new-onset depression, sustained an unexplained fall, and started walking cautiously. After 1 year, her depression resolved but she developed a dry cough. One year later, she experienced a more rapid decline in her gait with parkinsonism, visual difficulties with restricted vertical gaze, slowed horizontal and vertical saccades, dysphagia, apathy, and progressive cognitive decline, which led to her death 2 years later. The differential diagnosis, neuroimaging, and pathological findings are discussed, as well as their public health implications.
UR - https://www.scopus.com/pages/publications/85018932561
U2 - 10.1001/jamaneurol.2016.6159
DO - 10.1001/jamaneurol.2016.6159
M3 - Review article
C2 - 28264087
AN - SCOPUS:85018932561
SN - 2168-6149
VL - 74
SP - 591
EP - 596
JO - JAMA Neurology
JF - JAMA Neurology
IS - 5
ER -