Pre-prolactin accumulates in rat pituitary cells incubated with a threonine analog.

G. Hortin, I. Boime

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The proteolytic processing of rat pre-prolactin (Pre-Prl) to prolactin in isolated hemipituitaries was inhibited by the threonine analog, beta-hydroxynorvaline (Hnv). Pre-Prl accumulated as a major labeled intracellular product, even during pulse labeling longer than 2 h, but it was not secreted. Inhibition of Pre-Prl processing may result from incorporation of Hnv at the Pre-Prl cleavage site. This system offers the opportunity to study the disposition of an accumulated pre-protein in cells.

Original languageEnglish
Pages (from-to)7051-7054
Number of pages4
JournalJournal of Biological Chemistry
Volume255
Issue number15
StatePublished - Aug 10 1980
Externally publishedYes

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