TY - JOUR
T1 - Pre-pregnancy maternal obesity and the risk of preterm preeclampsia in the American primigravida
AU - Young, Omar M.
AU - Twedt, Roxanna
AU - Catov, Janet M.
N1 - Funding Information:
We are grateful to the anonymous referee for valuable comments which helped us to improve the presentation of our results. The European VLBI Network is a joint facility of independent Euro- pean, African, Asian, and North American radio astronomy institutes. Scientific results from data presented in this publication are derived from the following EVN project code: EF025. This work was supported by the Hungarian Scientific Research Fund (OTKA, NN110333), the China Ministry of Science and Technology (2013CB837900), and the China–Hungary Collaboration and Exchange Programme by the International Cooperation Bureau of the Chinese Academy of Sciences. The research leading to these results has received funding from the European Commission Seventh Framework Programme (FP/2007–2013) under grant agreement no. 283393 (RadioNet3). ZP acknowledges support of the MAGNA project from the International Space Science Institute (ISSI) in Bern, Switzerland. TA thanks the Shanghai Rising Star Program.
Funding Information:
We are grateful to the anonymous referee for valuable comments which helped us to improve the presentation of our results. The European VLBI Network is a joint facility of independent European, African, Asian, and North American radio astronomy institutes. Scientific results from data presented in this publication are derived from the following EVN project code: EF025. This work was supported by the Hungarian Scientific Research Fund (OTKA, NN110333), the China Ministry of Science and Technology (2013CB837900), and the China-Hungary Collaboration and Exchange Programme by the International Cooperation Bureau of the Chinese Academy of Sciences. The research leading to these results has received funding from the European Commission Seventh Framework Programme (FP/2007-2013) under grant agreement no. 283393 (RadioNet3). ZP acknowledges support of the MAGNA project from the International Space Science Institute (ISSI) in Bern, Switzerland. TA thanks the Shanghai Rising Star Program.
Publisher Copyright:
© 2016 The Obesity Society
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Objective: To estimate the risk of preterm preeclampsia in primiparous women by pre-pregnancy obesity class. Methods: A retrospective cohort study of primiparous women with singleton gestations was performed for deliveries from January 2003 to April 2014. Cases were stratified by delivery occurring either at ≥ 37 weeks or < 37 weeks. Pre-pregnancy maternal obesity was defined as a body mass index (BMI) ≥ 30 kg/m2. World Health Organization criteria were used to define BMI class of obesity. Multinomial logistic regression modeling estimated the association between term and preterm preeclampsia and pre-pregnancy obesity. Results: Of 28,361 women with complete pre-pregnancy BMI data, 2,588 women (9.1%) had a diagnosis of preeclampsia. Women who developed preeclampsia prior to 37 weeks (n = 784) were more likely to be women with obesity compared to women who developed preeclampsia after 37 weeks (33.1% vs. 25.3%, P = 0.0001). Compared to normal-weight women without preeclampsia, the risk of preterm preeclampsia increased proportionally with pre-pregnancy obesity class, with women with a BMI ≥ 40 kg/m2 having the greatest risk (RR 5.23, 95% CI: 3.86-7.09, P <0.001). Conclusions: The risk of preterm preeclampsia increased significantly as the severity of maternal pre-pregnancy obesity increased. Reduction in maternal pre-pregnancy BMI may be protective in mitigating such risk.
AB - Objective: To estimate the risk of preterm preeclampsia in primiparous women by pre-pregnancy obesity class. Methods: A retrospective cohort study of primiparous women with singleton gestations was performed for deliveries from January 2003 to April 2014. Cases were stratified by delivery occurring either at ≥ 37 weeks or < 37 weeks. Pre-pregnancy maternal obesity was defined as a body mass index (BMI) ≥ 30 kg/m2. World Health Organization criteria were used to define BMI class of obesity. Multinomial logistic regression modeling estimated the association between term and preterm preeclampsia and pre-pregnancy obesity. Results: Of 28,361 women with complete pre-pregnancy BMI data, 2,588 women (9.1%) had a diagnosis of preeclampsia. Women who developed preeclampsia prior to 37 weeks (n = 784) were more likely to be women with obesity compared to women who developed preeclampsia after 37 weeks (33.1% vs. 25.3%, P = 0.0001). Compared to normal-weight women without preeclampsia, the risk of preterm preeclampsia increased proportionally with pre-pregnancy obesity class, with women with a BMI ≥ 40 kg/m2 having the greatest risk (RR 5.23, 95% CI: 3.86-7.09, P <0.001). Conclusions: The risk of preterm preeclampsia increased significantly as the severity of maternal pre-pregnancy obesity increased. Reduction in maternal pre-pregnancy BMI may be protective in mitigating such risk.
UR - http://www.scopus.com/inward/record.url?scp=84990208067&partnerID=8YFLogxK
U2 - 10.1002/oby.21412
DO - 10.1002/oby.21412
M3 - Article
C2 - 26865510
AN - SCOPUS:84990208067
VL - 24
SP - 1226
EP - 1229
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 6
ER -