Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis

Sabrina Paganoni; Theodore Hyman; Amy Shui; Peggy Allred; Matthew Harms; Jingxia Liu; Nicholas Maragakis; David Schoenfeld; Hong Yu; Nazem Atassi; Merit Cudkowicz; Timothy M. Miller

doi:10.1002/mus.24688

Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis

Sabrina Paganoni, Theodore Hyman, Amy Shui, Peggy Allred, Matthew Harms, Jingxia Liu, Nicholas Maragakis, David Schoenfeld, Hong Yu, Nazem Atassi, Merit Cudkowicz, Timothy M. Miller

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Introduction: The aim of this study was to determine whether a history of pre-morbid type 2 diabetes mellitus (DM2) is a prognostic factor in amyotrophic lateral sclerosis (ALS). Methods: The relationship between DM2 and survival was analyzed in a study population consisting of 1,322 participants from 6 clinical trials. Results: Survival did not differ by diabetes status (log-rank test, P=0.98), but did differ by body mass index (BMI) (log-rank test, P=0.008). In multivariate analysis, there was no significant association between diabetes and survival (P=0.18), but the risk of reaching a survival endpoint decreased by 4% for each unit increase in baseline BMI (HR 0.96, 95% CI 0.94-0.99, P=0.001). DM2 was less prevalent among ALS clinical trial participants than predicted. Conclusions: A history of pre-morbid DM2 is not an independent prognostic factor in ALS clinical trial databases. The low DM2 prevalence rate should be examined in a large, prospective study to determine whether DM2 affects ALS risk.

Original language	English
Pages (from-to)	339-343
Number of pages	5
Journal	Muscle and Nerve
Volume	52
Issue number	3
DOIs	https://doi.org/10.1002/mus.24688
State	Published - Sep 1 2015

Keywords

ALS
BMI
Diabetes
Prognosis
Survival

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title = "Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis",

abstract = "Introduction: The aim of this study was to determine whether a history of pre-morbid type 2 diabetes mellitus (DM2) is a prognostic factor in amyotrophic lateral sclerosis (ALS). Methods: The relationship between DM2 and survival was analyzed in a study population consisting of 1,322 participants from 6 clinical trials. Results: Survival did not differ by diabetes status (log-rank test, P=0.98), but did differ by body mass index (BMI) (log-rank test, P=0.008). In multivariate analysis, there was no significant association between diabetes and survival (P=0.18), but the risk of reaching a survival endpoint decreased by 4% for each unit increase in baseline BMI (HR 0.96, 95% CI 0.94-0.99, P=0.001). DM2 was less prevalent among ALS clinical trial participants than predicted. Conclusions: A history of pre-morbid DM2 is not an independent prognostic factor in ALS clinical trial databases. The low DM2 prevalence rate should be examined in a large, prospective study to determine whether DM2 affects ALS risk.",

keywords = "ALS, BMI, Diabetes, Prognosis, Survival",

author = "Sabrina Paganoni and Theodore Hyman and Amy Shui and Peggy Allred and Matthew Harms and Jingxia Liu and Nicholas Maragakis and David Schoenfeld and Hong Yu and Nazem Atassi and Merit Cudkowicz and Miller, {Timothy M.}",

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doi = "10.1002/mus.24688",

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AU - Paganoni, Sabrina

AU - Hyman, Theodore

AU - Shui, Amy

AU - Allred, Peggy

AU - Harms, Matthew

AU - Liu, Jingxia

AU - Maragakis, Nicholas

AU - Schoenfeld, David

AU - Yu, Hong

AU - Atassi, Nazem

AU - Cudkowicz, Merit

AU - Miller, Timothy M.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Introduction: The aim of this study was to determine whether a history of pre-morbid type 2 diabetes mellitus (DM2) is a prognostic factor in amyotrophic lateral sclerosis (ALS). Methods: The relationship between DM2 and survival was analyzed in a study population consisting of 1,322 participants from 6 clinical trials. Results: Survival did not differ by diabetes status (log-rank test, P=0.98), but did differ by body mass index (BMI) (log-rank test, P=0.008). In multivariate analysis, there was no significant association between diabetes and survival (P=0.18), but the risk of reaching a survival endpoint decreased by 4% for each unit increase in baseline BMI (HR 0.96, 95% CI 0.94-0.99, P=0.001). DM2 was less prevalent among ALS clinical trial participants than predicted. Conclusions: A history of pre-morbid DM2 is not an independent prognostic factor in ALS clinical trial databases. The low DM2 prevalence rate should be examined in a large, prospective study to determine whether DM2 affects ALS risk.

AB - Introduction: The aim of this study was to determine whether a history of pre-morbid type 2 diabetes mellitus (DM2) is a prognostic factor in amyotrophic lateral sclerosis (ALS). Methods: The relationship between DM2 and survival was analyzed in a study population consisting of 1,322 participants from 6 clinical trials. Results: Survival did not differ by diabetes status (log-rank test, P=0.98), but did differ by body mass index (BMI) (log-rank test, P=0.008). In multivariate analysis, there was no significant association between diabetes and survival (P=0.18), but the risk of reaching a survival endpoint decreased by 4% for each unit increase in baseline BMI (HR 0.96, 95% CI 0.94-0.99, P=0.001). DM2 was less prevalent among ALS clinical trial participants than predicted. Conclusions: A history of pre-morbid DM2 is not an independent prognostic factor in ALS clinical trial databases. The low DM2 prevalence rate should be examined in a large, prospective study to determine whether DM2 affects ALS risk.

KW - ALS

KW - BMI

KW - Diabetes

KW - Prognosis

KW - Survival

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Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis

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