Pre-clinical MR elastography: principles, techniques, and applications

P. V. Bayly, J. R. Garbow

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Magnetic resonance elastography (MRE) is a method for measuring the mechanical properties of soft tissue in vivo, non-invasively, by imaging propagating shear waves in the tissue. The speed and attenuation of waves depends on the elastic and dissipative properties of the underlying material. Tissue mechanical properties are essential for biomechanical models and simulations, and may serve as markers of disease, injury, development, or recovery. MRE is already established as a clinical technique for detecting and characterizing liver disease. The potential of MRE for diagnosing or characterizing disease in other organs, including brain, breast, and heart is an active research area. Studies involving MRE in the pre-clinical setting, in phantoms and artificial biomaterials, in the mouse, and in other mammals, are critical to the development of MRE as a robust, reliable, and useful modality.

Original languageEnglish
Pages (from-to)73-83
Number of pages11
JournalJournal of Magnetic Resonance
Volume291
DOIs
StatePublished - Jun 2018

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