TY - JOUR
T1 - Practice patterns and outcomes associated with early sedation depth in mechanically ventilated patients
T2 - A systematic review protocol
AU - Stephens, Robert J.
AU - Dettmer, Matthew R.
AU - Roberts, Brian W.
AU - Fowler, Susan A.
AU - Fuller, Brian M.
N1 - Funding Information:
RJS received funding from Washington University Institute of Clinical and Translational Sciences Grant UL1 TR000448, subaward TL1 TR000449, from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH). BMF was funded by the KL2 Career Development Award, and this research was supported by Washington University Institute of Clinical and Translational Sciences (Grants UL1 TR000448 and KL2 TR000450) from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH). BMF was also funded by the Foundation for Barnes-Jewish Hospital Clinical and Translational Sciences Research Program (Grant #8041-88). BWR was supported by a grant from the National Institutes of Health/National Heart, Lung, and Blood Institute (K23HL126979).
Publisher Copyright:
© 2017 Article author(s).
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Introduction: Mechanical ventilation is a commonly performed intervention in critically ill patients. Frequently, these patients experience deep sedation early in their clinical course. Emerging data suggest that the practice of early deep sedation may negatively impact patient outcomes. The purpose of this review is to assess the world's literature to describe and determine the impact of early deep sedation on the outcomes of mechanically ventilated patients. Methods and analysis: Randomised controlled trials and non-randomised studies will be eligible for inclusion in this systematic review. With the assistance of a medical librarian, we will comprehensively search MEDLINE, Embase, Scopus, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews and Effects, and Cochrane Database of Systematic Reviews for peer-reviewed literature. Grey literature from appropriate professional society conferences, held from 2010 to 2017, will be reviewed manually. Two authors will independently review all search results, and disagreements will be resolved through arbitration by a third author. If appropriate, meta-analysis will be used for quantitative analysis of the data. Heterogeneity between studies will be assessed using the I 2 statistic. Ethics and dissemination: The proposed systematic review will not collect data that are associated with individual patients and does not require ethical approval. Results of this study will contribute to the understanding of early sedation, identify future research targets and guide early care in mechanically ventilated patients.
AB - Introduction: Mechanical ventilation is a commonly performed intervention in critically ill patients. Frequently, these patients experience deep sedation early in their clinical course. Emerging data suggest that the practice of early deep sedation may negatively impact patient outcomes. The purpose of this review is to assess the world's literature to describe and determine the impact of early deep sedation on the outcomes of mechanically ventilated patients. Methods and analysis: Randomised controlled trials and non-randomised studies will be eligible for inclusion in this systematic review. With the assistance of a medical librarian, we will comprehensively search MEDLINE, Embase, Scopus, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews and Effects, and Cochrane Database of Systematic Reviews for peer-reviewed literature. Grey literature from appropriate professional society conferences, held from 2010 to 2017, will be reviewed manually. Two authors will independently review all search results, and disagreements will be resolved through arbitration by a third author. If appropriate, meta-analysis will be used for quantitative analysis of the data. Heterogeneity between studies will be assessed using the I 2 statistic. Ethics and dissemination: The proposed systematic review will not collect data that are associated with individual patients and does not require ethical approval. Results of this study will contribute to the understanding of early sedation, identify future research targets and guide early care in mechanically ventilated patients.
KW - mechanical ventilation
KW - meta-analysis
KW - sedation
KW - systematic review
UR - http://www.scopus.com/inward/record.url?scp=85020684585&partnerID=8YFLogxK
U2 - 10.1136/bmjopen-2017-016437
DO - 10.1136/bmjopen-2017-016437
M3 - Review article
C2 - 28600379
AN - SCOPUS:85020684585
VL - 7
JO - BMJ Open
JF - BMJ Open
SN - 2044-6055
IS - 6
M1 - e016437
ER -