Practical closed-loop insulin delivery. A system for the maintenance of overnight euglycemia and the calculation of basal insulin requirements in insulin-dependent diabetics

N. H. White, D. Skor, J. V. Santiago

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

We evaluated a practical closed-loop system of insulin delivery consisting of hourly blood glucose determinations using glucose oxidase reagent strips and an intravenous infusion of insulin controlled by a commonly available controller. In 25 insulin-dependent diabetic subjects, this system was successful in achieving and maintaining near euglycemia (blood glucose, 101 ± 2 mg/dL, mean ± SE) in the fasting state between 0200 and 0800 hours. This system may be useful in the management of insulin-dependent diabetic patients in various hospital settings. Also, in 10 subjects treated subsequently using a continuous subcutaneous insulin infusion, the mean hourly insulin infusion rate using the described system correlated well (r = 0.92) with the optimal overnight basal rate needed during continuous subcutaneous insulin infusion therapy.

Original languageEnglish
Pages (from-to)210-213
Number of pages4
JournalAnnals of internal medicine
Volume97
Issue number2
DOIs
StatePublished - Jan 1 1982

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