PPARα: Savior or savage?

Jochen G. Schneider, Clay F. Semenkovich

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations

Abstract

The nuclear receptor PPARα is activated by drugs used to decrease heart disease risk by improving circulating lipids. New findings indicate that PPARα may decrease vascular disease by promoting the activity of a tumor suppressor in smooth muscle cells, a surprising mechanism since PPARα causes tumors in rodents.

Original languageEnglish
Pages (from-to)341-342
Number of pages2
JournalCell metabolism
Volume2
Issue number6
DOIs
StatePublished - Dec 1 2005

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