PPARα: Savior or savage?

Jochen G. Schneider; Clay F. Semenkovich

doi:10.1016/j.cmet.2005.11.006

PPARα: Savior or savage?

Jochen G. Schneider, Clay F. Semenkovich

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

The nuclear receptor PPARα is activated by drugs used to decrease heart disease risk by improving circulating lipids. New findings indicate that PPARα may decrease vascular disease by promoting the activity of a tumor suppressor in smooth muscle cells, a surprising mechanism since PPARα causes tumors in rodents.

Original language	English
Pages (from-to)	341-342
Number of pages	2
Journal	Cell metabolism
Volume	2
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2005.11.006
State	Published - Dec 2005

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10.1016/j.cmet.2005.11.006

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title = "PPARα: Savior or savage?",

abstract = "The nuclear receptor PPARα is activated by drugs used to decrease heart disease risk by improving circulating lipids. New findings indicate that PPARα may decrease vascular disease by promoting the activity of a tumor suppressor in smooth muscle cells, a surprising mechanism since PPARα causes tumors in rodents.",

author = "Schneider, {Jochen G.} and Semenkovich, {Clay F.}",

year = "2005",

month = dec,

doi = "10.1016/j.cmet.2005.11.006",

language = "English",

volume = "2",

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TY - JOUR

T1 - PPARα

T2 - Savior or savage?

AU - Schneider, Jochen G.

AU - Semenkovich, Clay F.

PY - 2005/12

Y1 - 2005/12

N2 - The nuclear receptor PPARα is activated by drugs used to decrease heart disease risk by improving circulating lipids. New findings indicate that PPARα may decrease vascular disease by promoting the activity of a tumor suppressor in smooth muscle cells, a surprising mechanism since PPARα causes tumors in rodents.

AB - The nuclear receptor PPARα is activated by drugs used to decrease heart disease risk by improving circulating lipids. New findings indicate that PPARα may decrease vascular disease by promoting the activity of a tumor suppressor in smooth muscle cells, a surprising mechanism since PPARα causes tumors in rodents.

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U2 - 10.1016/j.cmet.2005.11.006

DO - 10.1016/j.cmet.2005.11.006

M3 - Short survey

C2 - 16330317

AN - SCOPUS:33644875405

SN - 1550-4131

VL - 2

SP - 341

EP - 342

JO - Cell metabolism

JF - Cell metabolism

IS - 6

ER -

PPARα: Savior or savage?

Abstract

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