Powering a burnt bridges Brownian ratchet: A model for an extracellular motor driven by proteolysis of collagen

Saveez Saffarian, Hong Qian, Ivan Collier, Elliot Elson, Gregory Goldberg

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Biased diffusion of collagenase on collagen fibrils may represent the first observed adenosine triphosphate-independent extracellular molecular motor. The magnitude of force generated by the enzyme remains unclear. We propose a propulsion mechanism based on a burnt bridges Brownian ratchet model with a varying degree of coupling of the free energy from collagen proteolysis to the enzyme motion. When constrained by experimental observations, our model predicts 0.1 pN stall force for individual collagenase molecules. A dimer, surprisingly, can generate a force in the range of 5 pN, suggesting that the motor can be of biological significance.

Original languageEnglish
Article number041909
JournalPhysical Review E - Statistical, Nonlinear, and Soft Matter Physics
Volume73
Issue number4
DOIs
StatePublished - Apr 18 2006

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