TY - JOUR
T1 - Potential role of apoE in structural plasticity in the nervous system
T2 - Implications for disorders of the central nervous system
AU - Holtzman, David M.
AU - Fagan, Anne M.
N1 - Funding Information:
The authors thank Guojun Bu and Leonard Berg for critical review of the manuscript. DMH is supported by NIH grants AG13956 and AG05681, a grant from the Alzheimer’s Association, and a Paul Beeson Physician Faculty Scholars Award from the American Federation for Aging Research.
PY - 1998/8
Y1 - 1998/8
N2 - Apolipoprotein E (apoE) is a well characterized 299 amino acid protein that participates in the regulation of plasma cholesterol and lipid metabolism. In humans, apoE has three major protein isoforms: E2 (cys112, cys158); E3 (cys112, arg158); and E4 (arg112, arg158) that are encoded for by a single gene on chromosome 19. Genetic studies have shown that apoE4 is a risk factor for Alzheimer's disease (AD) as well as for poor outcome following certain injuries to the central nervous system (CNS). These genetic data, as well as other data reviewed herein, suggest that apoE may play an important role in the nervous system under certain conditions. This review focuses on studies demonstrating that apoE can modulate neuronal structure and the potential implication of these findings for its role following CNS injury, in AD, and in other neurodegenerative diseases.
AB - Apolipoprotein E (apoE) is a well characterized 299 amino acid protein that participates in the regulation of plasma cholesterol and lipid metabolism. In humans, apoE has three major protein isoforms: E2 (cys112, cys158); E3 (cys112, arg158); and E4 (arg112, arg158) that are encoded for by a single gene on chromosome 19. Genetic studies have shown that apoE4 is a risk factor for Alzheimer's disease (AD) as well as for poor outcome following certain injuries to the central nervous system (CNS). These genetic data, as well as other data reviewed herein, suggest that apoE may play an important role in the nervous system under certain conditions. This review focuses on studies demonstrating that apoE can modulate neuronal structure and the potential implication of these findings for its role following CNS injury, in AD, and in other neurodegenerative diseases.
UR - http://www.scopus.com/inward/record.url?scp=0031709748&partnerID=8YFLogxK
U2 - 10.1016/S1050-1738(98)00017-6
DO - 10.1016/S1050-1738(98)00017-6
M3 - Article
C2 - 14987560
AN - SCOPUS:0031709748
SN - 1050-1738
VL - 8
SP - 250
EP - 255
JO - Trends in Cardiovascular Medicine
JF - Trends in Cardiovascular Medicine
IS - 6
ER -