@article{429cadbd05364a8d97a9628436250f9b,
title = "Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: Discovery of N,N-diethyl-4-(5-hydroxyspiro-[chromene-2, 4′-piperidine]-4-yl)benzamide (ADL5859)",
abstract = "Selective δ opioid receptor agonists are promising potential therapeutic agents for the treatment of various types of pain conditions. A spirocyclic derivative was identified as a promising hit through screening. Subsequent lead optimization identified compound 20 (ADL5859) as a potent, selective, and orally bioavailable δ agonist. Compound 20 was selected as a clinical candidate for the treatment of pain.",
author = "{Le Bourdonnec}, Bertrand and Windh, {Rolf T.} and Ajello, {Christopher W.} and Leister, {Lara K.} and Minghua Gu and Chu, {Guo Hua} and Tuthill, {Paul A.} and Barker, {William M.} and Michael Koblish and Wiant, {Daniel D.} and Graczyk, {Thomas M.} and Serge Belanger and Cassel, {Joel A.} and Feschenko, {Marina S.} and Brogdon, {Bernice L.} and Smith, {Steven A.} and Christ, {David D.} and Derelanko, {Michael J.} and Steve Kutz and Little, {Patrick J.} and DeHaven, {Robert N.} and DeHaven-Hudkins, {Diane L.} and Dolle, {Roland E.}",
year = "2008",
month = oct,
day = "9",
doi = "10.1021/jm8008986",
language = "English",
volume = "51",
pages = "5893--5896",
journal = "Journal of Medicinal Chemistry",
issn = "0022-2623",
number = "19",
}