Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints

Guo Hua Chu; Minghua Gu; Joel A. Cassel; Serge Belanger; Thomas M. Graczyk; Robert N. Dehaven; Nathalie Conway-James; Mike Koblish; Patrick J. Little; Diane L. DeHaven-Hudkins; Roland E. Dolle

doi:10.1016/j.bmcl.2005.08.094

Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints

Guo Hua Chu, Minghua Gu, Joel A. Cassel, Serge Belanger, Thomas M. Graczyk, Robert N. Dehaven, Nathalie Conway-James, Mike Koblish, Patrick J. Little, Diane L. DeHaven-Hudkins, Roland E. Dolle

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Two novel chemical classes of kappa opioid receptor agonists, chroman-2-carboxamide derivatives and 2,3-dihydrobenzofuran-2-carboxamide derivatives, were synthesized. These agents exhibited high and selective affinity for the kappa opioid receptor.

Original language	English
Pages (from-to)	5114-5119
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	15
Issue number	23
DOIs	https://doi.org/10.1016/j.bmcl.2005.08.094
State	Published - Dec 1 2005

Keywords

Analgesic
Kappa opioid receptor agonists

Access to Document

10.1016/j.bmcl.2005.08.094

Cite this

Chu, G. H., Gu, M., Cassel, J. A., Belanger, S., Graczyk, T. M., Dehaven, R. N., Conway-James, N., Koblish, M., Little, P. J., DeHaven-Hudkins, D. L., & Dolle, R. E. (2005). Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints. Bioorganic and Medicinal Chemistry Letters, 15(23), 5114-5119. https://doi.org/10.1016/j.bmcl.2005.08.094

@article{77c97ff5face4598a9a7a6c120c65e57,

title = "Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints",

abstract = "Two novel chemical classes of kappa opioid receptor agonists, chroman-2-carboxamide derivatives and 2,3-dihydrobenzofuran-2-carboxamide derivatives, were synthesized. These agents exhibited high and selective affinity for the kappa opioid receptor.",

keywords = "Analgesic, Kappa opioid receptor agonists",

author = "Chu, {Guo Hua} and Minghua Gu and Cassel, {Joel A.} and Serge Belanger and Graczyk, {Thomas M.} and Dehaven, {Robert N.} and Nathalie Conway-James and Mike Koblish and Little, {Patrick J.} and DeHaven-Hudkins, {Diane L.} and Dolle, {Roland E.}",

year = "2005",

month = dec,

day = "1",

doi = "10.1016/j.bmcl.2005.08.094",

language = "English",

volume = "15",

pages = "5114--5119",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

number = "23",

}

Chu, GH, Gu, M, Cassel, JA, Belanger, S, Graczyk, TM, Dehaven, RN, Conway-James, N, Koblish, M, Little, PJ, DeHaven-Hudkins, DL & Dolle, RE 2005, 'Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints', Bioorganic and Medicinal Chemistry Letters, vol. 15, no. 23, pp. 5114-5119. https://doi.org/10.1016/j.bmcl.2005.08.094

TY - JOUR

T1 - Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints

AU - Chu, Guo Hua

AU - Gu, Minghua

AU - Cassel, Joel A.

AU - Belanger, Serge

AU - Graczyk, Thomas M.

AU - Dehaven, Robert N.

AU - Conway-James, Nathalie

AU - Koblish, Mike

AU - Little, Patrick J.

AU - DeHaven-Hudkins, Diane L.

AU - Dolle, Roland E.

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Two novel chemical classes of kappa opioid receptor agonists, chroman-2-carboxamide derivatives and 2,3-dihydrobenzofuran-2-carboxamide derivatives, were synthesized. These agents exhibited high and selective affinity for the kappa opioid receptor.

AB - Two novel chemical classes of kappa opioid receptor agonists, chroman-2-carboxamide derivatives and 2,3-dihydrobenzofuran-2-carboxamide derivatives, were synthesized. These agents exhibited high and selective affinity for the kappa opioid receptor.

KW - Analgesic

KW - Kappa opioid receptor agonists

UR - http://www.scopus.com/inward/record.url?scp=26844490394&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2005.08.094

DO - 10.1016/j.bmcl.2005.08.094

M3 - Article

C2 - 16203140

AN - SCOPUS:26844490394

SN - 0960-894X

VL - 15

SP - 5114

EP - 5119

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Potent and highly selective kappa opioid receptor agonists incorporating chroman- and 2,3-dihydrobenzofuran-based constraints

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this