TY - JOUR
T1 - Potassium currents in the heart
T2 - functional roles in repolarization, arrhythmia and therapeutics
AU - Chiamvimonvat, Nipavan
AU - Chen-Izu, Ye
AU - Clancy, Colleen E.
AU - Deschenes, Isabelle
AU - Dobrev, Dobromir
AU - Heijman, Jordi
AU - Izu, Leighton
AU - Qu, Zhilin
AU - Ripplinger, Crystal M.
AU - Vandenberg, Jamie I.
AU - Weiss, James N.
AU - Koren, Gideon
AU - Banyasz, Tamas
AU - Grandi, Eleonora
AU - Sanguinetti, Michael C.
AU - Bers, Donald M.
AU - Nerbonne, Jeanne M.
N1 - Publisher Copyright:
© 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Abstract: This is the second of the two White Papers from the fourth UC Davis Cardiovascular Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling and Arrhythmias (3–4 March 2016), a biennial event that brings together leading experts in different fields of cardiovascular research. The theme of the 2016 symposium was ‘K+ channels and regulation’, and the objectives of the conference were severalfold: (1) to identify current knowledge gaps; (2) to understand what may go wrong in the diseased heart and why; (3) to identify possible novel therapeutic targets; and (4) to further the development of systems biology approaches to decipher the molecular mechanisms and treatment of cardiac arrhythmias. The sessions of the Symposium focusing on the functional roles of the cardiac K+ channel in health and disease, as well as K+ channels as therapeutic targets, were contributed by Ye Chen-Izu, Gideon Koren, James Weiss, David Paterson, David Christini, Dobromir Dobrev, Jordi Heijman, Thomas O'Hara, Crystal Ripplinger, Zhilin Qu, Jamie Vandenberg, Colleen Clancy, Isabelle Deschenes, Leighton Izu, Tamas Banyasz, Andras Varro, Heike Wulff, Eleonora Grandi, Michael Sanguinetti, Donald Bers, Jeanne Nerbonne and Nipavan Chiamvimonvat as speakers and panel discussants. This article summarizes state-of-the-art knowledge and controversies on the functional roles of cardiac K+ channels in normal and diseased heart. We endeavour to integrate current knowledge at multiple scales, from the single cell to the whole organ levels, and from both experimental and computational studies.
AB - Abstract: This is the second of the two White Papers from the fourth UC Davis Cardiovascular Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling and Arrhythmias (3–4 March 2016), a biennial event that brings together leading experts in different fields of cardiovascular research. The theme of the 2016 symposium was ‘K+ channels and regulation’, and the objectives of the conference were severalfold: (1) to identify current knowledge gaps; (2) to understand what may go wrong in the diseased heart and why; (3) to identify possible novel therapeutic targets; and (4) to further the development of systems biology approaches to decipher the molecular mechanisms and treatment of cardiac arrhythmias. The sessions of the Symposium focusing on the functional roles of the cardiac K+ channel in health and disease, as well as K+ channels as therapeutic targets, were contributed by Ye Chen-Izu, Gideon Koren, James Weiss, David Paterson, David Christini, Dobromir Dobrev, Jordi Heijman, Thomas O'Hara, Crystal Ripplinger, Zhilin Qu, Jamie Vandenberg, Colleen Clancy, Isabelle Deschenes, Leighton Izu, Tamas Banyasz, Andras Varro, Heike Wulff, Eleonora Grandi, Michael Sanguinetti, Donald Bers, Jeanne Nerbonne and Nipavan Chiamvimonvat as speakers and panel discussants. This article summarizes state-of-the-art knowledge and controversies on the functional roles of cardiac K+ channels in normal and diseased heart. We endeavour to integrate current knowledge at multiple scales, from the single cell to the whole organ levels, and from both experimental and computational studies.
KW - K channel blockers
KW - atrial fibrillation
KW - cardiac K channels
KW - cardiac arrhythmia
KW - cardiac repolarization
KW - computational modeling
KW - hERG channel
KW - long QT syndrome
UR - http://www.scopus.com/inward/record.url?scp=85008489707&partnerID=8YFLogxK
U2 - 10.1113/JP272883
DO - 10.1113/JP272883
M3 - Article
C2 - 27808412
AN - SCOPUS:85008489707
SN - 0022-3751
VL - 595
SP - 2229
EP - 2252
JO - Journal of Physiology
JF - Journal of Physiology
IS - 7
ER -