Potassium channels and uterine function

Adam M. Brainard; Victoria P. Korovkina; Sarah K. England

doi:10.1016/j.semcdb.2007.05.008

Potassium channels and uterine function

Adam M. Brainard, Victoria P. Korovkina, Sarah K. England

Research output: Contribution to journal › Review article › peer-review

84 Scopus citations

Abstract

Ion channels are effector proteins that mediate uterine excitability throughout gestation. This review will focus primarily on the role of potassium channels in regulating myometrial tone in pregnancy and labor contractions. During gestation, potassium channels maintain the uterus in a state of quiescence by contributing to the resting membrane potential and counteracting contractile stimuli. This review summarizes the current knowledge about the significance of the potassium channels in maintaining a normal gestational period and initiating labor contractions at term.

Original language	English
Pages (from-to)	332-339
Number of pages	8
Journal	Seminars in Cell and Developmental Biology
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/j.semcdb.2007.05.008
State	Published - Jun 2007

Keywords

Labor
Myometrium
Potassium channel
Pregnancy

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10.1016/j.semcdb.2007.05.008

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title = "Potassium channels and uterine function",

abstract = "Ion channels are effector proteins that mediate uterine excitability throughout gestation. This review will focus primarily on the role of potassium channels in regulating myometrial tone in pregnancy and labor contractions. During gestation, potassium channels maintain the uterus in a state of quiescence by contributing to the resting membrane potential and counteracting contractile stimuli. This review summarizes the current knowledge about the significance of the potassium channels in maintaining a normal gestational period and initiating labor contractions at term.",

keywords = "Labor, Myometrium, Potassium channel, Pregnancy",

author = "Brainard, {Adam M.} and Korovkina, {Victoria P.} and England, {Sarah K.}",

note = "Funding Information: This work was supported by grants from the National Institutes of Health (HD-037831 to S.K.E.) and the March of Dimes (#21-FY04-169 to S.K.E.).",

year = "2007",

month = jun,

doi = "10.1016/j.semcdb.2007.05.008",

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journal = "Seminars in Cell and Developmental Biology",

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AU - Brainard, Adam M.

AU - Korovkina, Victoria P.

AU - England, Sarah K.

N1 - Funding Information: This work was supported by grants from the National Institutes of Health (HD-037831 to S.K.E.) and the March of Dimes (#21-FY04-169 to S.K.E.).

PY - 2007/6

Y1 - 2007/6

N2 - Ion channels are effector proteins that mediate uterine excitability throughout gestation. This review will focus primarily on the role of potassium channels in regulating myometrial tone in pregnancy and labor contractions. During gestation, potassium channels maintain the uterus in a state of quiescence by contributing to the resting membrane potential and counteracting contractile stimuli. This review summarizes the current knowledge about the significance of the potassium channels in maintaining a normal gestational period and initiating labor contractions at term.

AB - Ion channels are effector proteins that mediate uterine excitability throughout gestation. This review will focus primarily on the role of potassium channels in regulating myometrial tone in pregnancy and labor contractions. During gestation, potassium channels maintain the uterus in a state of quiescence by contributing to the resting membrane potential and counteracting contractile stimuli. This review summarizes the current knowledge about the significance of the potassium channels in maintaining a normal gestational period and initiating labor contractions at term.

KW - Labor

KW - Myometrium

KW - Potassium channel

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=34547681636&partnerID=8YFLogxK

U2 - 10.1016/j.semcdb.2007.05.008

DO - 10.1016/j.semcdb.2007.05.008

M3 - Review article

C2 - 17596977

AN - SCOPUS:34547681636

SN - 1084-9521

VL - 18

SP - 332

EP - 339

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

IS - 3

ER -

Potassium channels and uterine function

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Keywords

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