TY - JOUR
T1 - Potassium channel openers
T2 - Are they effective as pretreatment or additives to cardioplegia?
AU - Ducko, Christopher T.
AU - Stephenson, Edward R.
AU - Mark Jayawant, A.
AU - Vigilance, Deon W.
AU - Damiano, Ralph J.
PY - 2000/5/1
Y1 - 2000/5/1
N2 - Background. This study was designed to test the hypothesis that the potassium channel opener pinacidil (Pin) as a pretreatment (PT) agent or additive to St. Thomas' solution (StT) could enhance myocardial protection. Methods. In a parabiotic rabbit Langendorff model, 36 hearts underwent global normothermic ischemia (1 hour) followed by reperfusion (30 minutes). Cardioplegia (50 mL, every 20 minutes) consisted of: StT; PinPT/StT, where Pin PT preceded StT arrest; Pin alone; Pin in StT (Pin/StT); and Pin in low potassium StT. Systolic function after reperfusion (percent recovery of developed pressure) and compliance (diastolic slope from pressure-volume relationship) were measured. Results. There was no significant difference between StT and PinPT/StT in percent recovery of developed pressure (51.54% ± 3.5%, 42.17% ± 4.0%, respectively) or compliance. Likewise, no significant differences occurred between Pin, StT, Pin/StT, and Pin in low potassium StT in percent recovery of developed pressure (58.99% ± 4.8%, 51.54% ± 3.5%, 53.09% ± 3.2%, 66.43% ± 7.3%, respectively) or compliance. Conclusions. Pin is as effective a cardioplegic agent as StT; however, its use as a pretreatment or additive to traditional and Pin in low potassium StT provided no additional benefit in functional recovery. (C) 2000 by The Society of Thoracic Surgeons.
AB - Background. This study was designed to test the hypothesis that the potassium channel opener pinacidil (Pin) as a pretreatment (PT) agent or additive to St. Thomas' solution (StT) could enhance myocardial protection. Methods. In a parabiotic rabbit Langendorff model, 36 hearts underwent global normothermic ischemia (1 hour) followed by reperfusion (30 minutes). Cardioplegia (50 mL, every 20 minutes) consisted of: StT; PinPT/StT, where Pin PT preceded StT arrest; Pin alone; Pin in StT (Pin/StT); and Pin in low potassium StT. Systolic function after reperfusion (percent recovery of developed pressure) and compliance (diastolic slope from pressure-volume relationship) were measured. Results. There was no significant difference between StT and PinPT/StT in percent recovery of developed pressure (51.54% ± 3.5%, 42.17% ± 4.0%, respectively) or compliance. Likewise, no significant differences occurred between Pin, StT, Pin/StT, and Pin in low potassium StT in percent recovery of developed pressure (58.99% ± 4.8%, 51.54% ± 3.5%, 53.09% ± 3.2%, 66.43% ± 7.3%, respectively) or compliance. Conclusions. Pin is as effective a cardioplegic agent as StT; however, its use as a pretreatment or additive to traditional and Pin in low potassium StT provided no additional benefit in functional recovery. (C) 2000 by The Society of Thoracic Surgeons.
UR - http://www.scopus.com/inward/record.url?scp=0033919518&partnerID=8YFLogxK
U2 - 10.1016/S0003-4975(00)01085-7
DO - 10.1016/S0003-4975(00)01085-7
M3 - Article
C2 - 10881806
AN - SCOPUS:0033919518
VL - 69
SP - 1363
EP - 1368
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
SN - 0003-4975
IS - 5
ER -