TY - JOUR
T1 - Potassium channel openers
T2 - Are they effective as pretreatment or additives to cardioplegia?
AU - Ducko, Christopher T.
AU - Stephenson, Edward R.
AU - Mark Jayawant, A.
AU - Vigilance, Deon W.
AU - Damiano, Ralph J.
N1 - Funding Information:
We gratefully acknowledge the technical assistance of Karen Reigle and the generous donation of pinacidil by Leo Pharmaceutical Products, Ltd. This work was supported by National Institutes of Health National Research Service Award grant HL09925-01 (Christopher T. Ducko, MD, Ralph J. Damiano, Jr) and National Institutes of Health RO1 HL51032-04 (Ralph J. Damiano Jr, MD).
PY - 2000/5
Y1 - 2000/5
N2 - Background. This study was designed to test the hypothesis that the potassium channel opener pinacidil (Pin) as a pretreatment (PT) agent or additive to St. Thomas' solution (StT) could enhance myocardial protection. Methods. In a parabiotic rabbit Langendorff model, 36 hearts underwent global normothermic ischemia (1 hour) followed by reperfusion (30 minutes). Cardioplegia (50 mL, every 20 minutes) consisted of: StT; PinPT/StT, where Pin PT preceded StT arrest; Pin alone; Pin in StT (Pin/StT); and Pin in low potassium StT. Systolic function after reperfusion (percent recovery of developed pressure) and compliance (diastolic slope from pressure-volume relationship) were measured. Results. There was no significant difference between StT and PinPT/StT in percent recovery of developed pressure (51.54% ± 3.5%, 42.17% ± 4.0%, respectively) or compliance. Likewise, no significant differences occurred between Pin, StT, Pin/StT, and Pin in low potassium StT in percent recovery of developed pressure (58.99% ± 4.8%, 51.54% ± 3.5%, 53.09% ± 3.2%, 66.43% ± 7.3%, respectively) or compliance. Conclusions. Pin is as effective a cardioplegic agent as StT; however, its use as a pretreatment or additive to traditional and Pin in low potassium StT provided no additional benefit in functional recovery. (C) 2000 by The Society of Thoracic Surgeons.
AB - Background. This study was designed to test the hypothesis that the potassium channel opener pinacidil (Pin) as a pretreatment (PT) agent or additive to St. Thomas' solution (StT) could enhance myocardial protection. Methods. In a parabiotic rabbit Langendorff model, 36 hearts underwent global normothermic ischemia (1 hour) followed by reperfusion (30 minutes). Cardioplegia (50 mL, every 20 minutes) consisted of: StT; PinPT/StT, where Pin PT preceded StT arrest; Pin alone; Pin in StT (Pin/StT); and Pin in low potassium StT. Systolic function after reperfusion (percent recovery of developed pressure) and compliance (diastolic slope from pressure-volume relationship) were measured. Results. There was no significant difference between StT and PinPT/StT in percent recovery of developed pressure (51.54% ± 3.5%, 42.17% ± 4.0%, respectively) or compliance. Likewise, no significant differences occurred between Pin, StT, Pin/StT, and Pin in low potassium StT in percent recovery of developed pressure (58.99% ± 4.8%, 51.54% ± 3.5%, 53.09% ± 3.2%, 66.43% ± 7.3%, respectively) or compliance. Conclusions. Pin is as effective a cardioplegic agent as StT; however, its use as a pretreatment or additive to traditional and Pin in low potassium StT provided no additional benefit in functional recovery. (C) 2000 by The Society of Thoracic Surgeons.
UR - http://www.scopus.com/inward/record.url?scp=0033919518&partnerID=8YFLogxK
U2 - 10.1016/S0003-4975(00)01085-7
DO - 10.1016/S0003-4975(00)01085-7
M3 - Article
C2 - 10881806
AN - SCOPUS:0033919518
VL - 69
SP - 1363
EP - 1368
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
SN - 0003-4975
IS - 5
ER -