Considerable indirect evidence suggests that vitamin K functions in prothrombin synthesis at a step in which a liver precursor protein is converted to prothrombin by the attachment of a calcium binding function. This hypothesized precursor has now been isolated from the liver of rats treated with warfarin and is being characterized. An in vitro system that will convert the precursor to prothrombin on addition of the vitamin has also been developed.
|Number of pages||8|
|Journal||Mayo Clinic Proceedings|
|State||Published - Dec 1 1974|