Postribosomal function of vitamin k in prothrombin synthesis

J. W. Suttie, G. A. Grant, C. T. Esmon, D. V. Shah

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Considerable indirect evidence suggests that vitamin K functions in prothrombin synthesis at a step in which a liver precursor protein is converted to prothrombin by the attachment of a calcium binding function. This hypothesized precursor has now been isolated from the liver of rats treated with warfarin and is being characterized. An in vitro system that will convert the precursor to prothrombin on addition of the vitamin has also been developed.

Original languageEnglish
Pages (from-to)933-940
Number of pages8
JournalMayo Clinic Proceedings
Issue number12
StatePublished - Dec 1 1974


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