Postprandial Chylomicron Output and Transport Through Intestinal Lymphatics Are Not Impaired in Active Crohn's Disease

Li Hao Huang; Parakkal Deepak; Matthew A. Ciorba; Bettina Mittendorfer; Bruce W. Patterson; Gwendalyn J. Randolph

doi:10.1053/j.gastro.2020.07.012

Postprandial Chylomicron Output and Transport Through Intestinal Lymphatics Are Not Impaired in Active Crohn's Disease

Li Hao Huang, Parakkal Deepak, Matthew A. Ciorba, Bettina Mittendorfer, Bruce W. Patterson, Gwendalyn J. Randolph

Research output: Contribution to journal › Short survey › peer-review

Original language	English
Pages (from-to)	1955-1957.e2
Journal	Gastroenterology
Volume	159
Issue number	5
DOIs	https://doi.org/10.1053/j.gastro.2020.07.012
State	Published - Nov 2020

Keywords

Chylomicron
Enterocyte
Hormone
Lipoprotein
Trafficking
Transport

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10.1053/j.gastro.2020.07.012

Cite this

@article{5d14241eeb1f4a8695bf6c30eed08218,

title = "Postprandial Chylomicron Output and Transport Through Intestinal Lymphatics Are Not Impaired in Active Crohn's Disease",

keywords = "Chylomicron, Enterocyte, Hormone, Lipoprotein, Trafficking, Transport",

author = "Huang, {Li Hao} and Parakkal Deepak and Ciorba, {Matthew A.} and Bettina Mittendorfer and Patterson, {Bruce W.} and Randolph, {Gwendalyn J.}",

note = "Funding Information: The authors are indebted to those who had important roles in advising on methods including statistics, providing technical assistance, recruiting patients, and/or providing overall advice and resources, including Washington University colleagues Nicole K. H. Yiew, Shashi B. Kumar, George P. Christophi, Adewole L. Okunade, Ling Chen, Sewuese E. Akuse, Adam J. Bittel, W. Todd Cade, and Nicholas O. Davidson. We thank Shaji Chacko (Baylor University) and the Baylor Children's Nutrition Research Center core facility for mass spectroscopy analysis of breath samples. The authors thank Ross Kossina and Gregory Strout for assistance with electron microscopy, performed at the Washington University Center for Cellular Imaging , which is supported in part by the Children{\textquoteright}s Discovery Institute of Washington University and St Louis Children{\textquoteright}s Hospital (CDI-CORE-2015-505 and CDI-CORE-2019-813) and the Foundation for Barnes-Jewish Hospital (3770 and 4642). The authors extend additional thanks to the nursing and kitchen staff of the Clinical Research and Translational Unit for their expert assistance. The authors are grateful for the advice and insight generously shared in conversations with Drs Robert Hirten and Jean-Frederic Colombel (Mount Sinai) and Elizabeth Parks (University of Missouri). Funding Information: Funding This work was funded by National Institutes of Health (NIH) grant DP1 DK1109668 and the Rainin Foundation (to Gwendalyn J. Randolph) and American Heart Association Career Development Award (18CDA34110273 to Li-Hao Huang). Additional funding for resources accessed at Washington University core facilities included the Digestive Diseases Research Core Center (P30 DK052574), Washington University Nutrition Obesity Research Center (P30 DK056341), the Institute of Clinical and Translational Science (UL1TR002345), and the Diabetes Research Center (NIH P30 DK020579). Washington University Inflammatory Bowel Disease Center research is supported by the Lawrence C. Pakula, MD, Inflammatory Bowel Disease Innovation Fund and givinitallforguts.org (to Matthew A. Ciorba).The authors are indebted to those who had important roles in advising on methods including statistics, providing technical assistance, recruiting patients, and/or providing overall advice and resources, including Washington University colleagues Nicole K. H. Yiew, Shashi B. Kumar, George P. Christophi, Adewole L. Okunade, Ling Chen, Sewuese E. Akuse, Adam J. Bittel, W. Todd Cade, and Nicholas O. Davidson. We thank Shaji Chacko (Baylor University) and the Baylor Children's Nutrition Research Center core facility for mass spectroscopy analysis of breath samples. The authors thank Ross Kossina and Gregory Strout for assistance with electron microscopy, performed at the Washington University Center for Cellular Imaging, which is supported in part by the Children's Discovery Institute of Washington University and St Louis Children's Hospital (CDI-CORE-2015-505 and CDI-CORE-2019-813) and the Foundation for Barnes-Jewish Hospital (3770 and 4642). The authors extend additional thanks to the nursing and kitchen staff of the Clinical Research and Translational Unit for their expert assistance. The authors are grateful for the advice and insight generously shared in conversations with Drs Robert Hirten and Jean-Frederic Colombel (Mount Sinai) and Elizabeth Parks (University of Missouri). Li-Hao Huang, PhD (Data curation: Equal; Formal analysis: Equal; Investigation: Lead; Methodology: Equal; Validation: Lead; Visualization: Equal; Writing – original draft: Equal; Writing – review & editing: Supporting); Parakkal Deepak, MD (Conceptualization: Supporting; Investigation: Supporting; Methodology: Supporting; Writing – review & editing: Supporting); Matthew A. Ciorba, MD (Conceptualization: Supporting; Methodology: Supporting; Supervision: Supporting; Writing – review & editing: Supporting); Bettina Mittendorfer, PhD (Conceptualization: Supporting; Data curation: Supporting; Methodology: Supporting; Resources: Supporting; Writing – review & editing: Supporting); Bruce W. Patterson, PhD (Conceptualization: Supporting; Formal analysis: Lead; Methodology: Lead; Supervision: Supporting; Validation: Equal; Visualization: Supporting; Writing – review & editing: Supporting); Gwendalyn J. Randolph, PhD (Conceptualization: Lead; Data curation: Equal; Formal analysis: Equal; Funding acquisition: Lead; Investigation: Supporting; Methodology: Supporting; Project administration: Lead; Resources: Lead; Supervision: Lead; Validation: Lead; Visualization: Equal; Writing – original draft: Lead; Writing – review & editing: Supporting). Funding Information: Funding This work was funded by National Institutes of Health (NIH) grant DP1 DK1109668 and the Rainin Foundation (to Gwendalyn J. Randolph) and American Heart Association Career Development Award (18CDA34110273 to Li-Hao Huang). Additional funding for resources accessed at Washington University core facilities included the Digestive Diseases Research Core Center (P30 DK052574), Washington University Nutrition Obesity Research Center (P30 DK056341), the Institute of Clinical and Translational Science (UL1TR002345), and the Diabetes Research Center (NIH P30 DK020579). Washington University Inflammatory Bowel Disease Center research is supported by the Lawrence C. Pakula, MD, Inflammatory Bowel Disease Innovation Fund and givinitallforguts.org (to Matthew A. Ciorba). ",

year = "2020",

month = nov,

doi = "10.1053/j.gastro.2020.07.012",

language = "English",

volume = "159",

pages = "1955--1957.e2",

journal = "Gastroenterology",

issn = "0016-5085",

number = "5",

}

TY - JOUR

T1 - Postprandial Chylomicron Output and Transport Through Intestinal Lymphatics Are Not Impaired in Active Crohn's Disease

AU - Huang, Li Hao

AU - Deepak, Parakkal

AU - Ciorba, Matthew A.

AU - Mittendorfer, Bettina

AU - Patterson, Bruce W.

AU - Randolph, Gwendalyn J.

N1 - Funding Information: The authors are indebted to those who had important roles in advising on methods including statistics, providing technical assistance, recruiting patients, and/or providing overall advice and resources, including Washington University colleagues Nicole K. H. Yiew, Shashi B. Kumar, George P. Christophi, Adewole L. Okunade, Ling Chen, Sewuese E. Akuse, Adam J. Bittel, W. Todd Cade, and Nicholas O. Davidson. We thank Shaji Chacko (Baylor University) and the Baylor Children's Nutrition Research Center core facility for mass spectroscopy analysis of breath samples. The authors thank Ross Kossina and Gregory Strout for assistance with electron microscopy, performed at the Washington University Center for Cellular Imaging , which is supported in part by the Children’s Discovery Institute of Washington University and St Louis Children’s Hospital (CDI-CORE-2015-505 and CDI-CORE-2019-813) and the Foundation for Barnes-Jewish Hospital (3770 and 4642). The authors extend additional thanks to the nursing and kitchen staff of the Clinical Research and Translational Unit for their expert assistance. The authors are grateful for the advice and insight generously shared in conversations with Drs Robert Hirten and Jean-Frederic Colombel (Mount Sinai) and Elizabeth Parks (University of Missouri). Funding Information: Funding This work was funded by National Institutes of Health (NIH) grant DP1 DK1109668 and the Rainin Foundation (to Gwendalyn J. Randolph) and American Heart Association Career Development Award (18CDA34110273 to Li-Hao Huang). Additional funding for resources accessed at Washington University core facilities included the Digestive Diseases Research Core Center (P30 DK052574), Washington University Nutrition Obesity Research Center (P30 DK056341), the Institute of Clinical and Translational Science (UL1TR002345), and the Diabetes Research Center (NIH P30 DK020579). Washington University Inflammatory Bowel Disease Center research is supported by the Lawrence C. Pakula, MD, Inflammatory Bowel Disease Innovation Fund and givinitallforguts.org (to Matthew A. Ciorba).The authors are indebted to those who had important roles in advising on methods including statistics, providing technical assistance, recruiting patients, and/or providing overall advice and resources, including Washington University colleagues Nicole K. H. Yiew, Shashi B. Kumar, George P. Christophi, Adewole L. Okunade, Ling Chen, Sewuese E. Akuse, Adam J. Bittel, W. Todd Cade, and Nicholas O. Davidson. We thank Shaji Chacko (Baylor University) and the Baylor Children's Nutrition Research Center core facility for mass spectroscopy analysis of breath samples. The authors thank Ross Kossina and Gregory Strout for assistance with electron microscopy, performed at the Washington University Center for Cellular Imaging, which is supported in part by the Children's Discovery Institute of Washington University and St Louis Children's Hospital (CDI-CORE-2015-505 and CDI-CORE-2019-813) and the Foundation for Barnes-Jewish Hospital (3770 and 4642). The authors extend additional thanks to the nursing and kitchen staff of the Clinical Research and Translational Unit for their expert assistance. The authors are grateful for the advice and insight generously shared in conversations with Drs Robert Hirten and Jean-Frederic Colombel (Mount Sinai) and Elizabeth Parks (University of Missouri). Li-Hao Huang, PhD (Data curation: Equal; Formal analysis: Equal; Investigation: Lead; Methodology: Equal; Validation: Lead; Visualization: Equal; Writing – original draft: Equal; Writing – review & editing: Supporting); Parakkal Deepak, MD (Conceptualization: Supporting; Investigation: Supporting; Methodology: Supporting; Writing – review & editing: Supporting); Matthew A. Ciorba, MD (Conceptualization: Supporting; Methodology: Supporting; Supervision: Supporting; Writing – review & editing: Supporting); Bettina Mittendorfer, PhD (Conceptualization: Supporting; Data curation: Supporting; Methodology: Supporting; Resources: Supporting; Writing – review & editing: Supporting); Bruce W. Patterson, PhD (Conceptualization: Supporting; Formal analysis: Lead; Methodology: Lead; Supervision: Supporting; Validation: Equal; Visualization: Supporting; Writing – review & editing: Supporting); Gwendalyn J. Randolph, PhD (Conceptualization: Lead; Data curation: Equal; Formal analysis: Equal; Funding acquisition: Lead; Investigation: Supporting; Methodology: Supporting; Project administration: Lead; Resources: Lead; Supervision: Lead; Validation: Lead; Visualization: Equal; Writing – original draft: Lead; Writing – review & editing: Supporting). Funding Information: Funding This work was funded by National Institutes of Health (NIH) grant DP1 DK1109668 and the Rainin Foundation (to Gwendalyn J. Randolph) and American Heart Association Career Development Award (18CDA34110273 to Li-Hao Huang). Additional funding for resources accessed at Washington University core facilities included the Digestive Diseases Research Core Center (P30 DK052574), Washington University Nutrition Obesity Research Center (P30 DK056341), the Institute of Clinical and Translational Science (UL1TR002345), and the Diabetes Research Center (NIH P30 DK020579). Washington University Inflammatory Bowel Disease Center research is supported by the Lawrence C. Pakula, MD, Inflammatory Bowel Disease Innovation Fund and givinitallforguts.org (to Matthew A. Ciorba).

PY - 2020/11

Y1 - 2020/11

KW - Chylomicron

KW - Enterocyte

KW - Hormone

KW - Lipoprotein

KW - Trafficking

KW - Transport

UR - http://www.scopus.com/inward/record.url?scp=85096166696&partnerID=8YFLogxK

U2 - 10.1053/j.gastro.2020.07.012

DO - 10.1053/j.gastro.2020.07.012

M3 - Short survey

C2 - 32681923

AN - SCOPUS:85096166696

VL - 159

SP - 1955-1957.e2

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 5

ER -

Postprandial Chylomicron Output and Transport Through Intestinal Lymphatics Are Not Impaired in Active Crohn's Disease

Keywords

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