Postoperative radiation performed at the same surgical facility associated with improved overall survival in oral cavity squamous cell carcinoma

Arya Amini; William A. Stokes; Bernard L. Jones; Sagus Sampath; Robert S. Kang; Thomas J. Gernon; Ellie G. Maghami; Erminia Massarelli; Cathy J. Bradley; Sana D. Karam

doi:10.1002/hed.25697

Postoperative radiation performed at the same surgical facility associated with improved overall survival in oral cavity squamous cell carcinoma

Arya Amini, William A. Stokes, Bernard L. Jones, Sagus Sampath, Robert S. Kang, Thomas J. Gernon, Ellie G. Maghami, Erminia Massarelli, Cathy J. Bradley, Sana D. Karam

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background: The purpose of this analysis is to evaluate whether postoperative radiotherapy (PORT) at the same facility as surgery portends to better survival outcomes compared to PORT given at a different facility. Methods: Patients underwent upfront surgery at the National Cancer Database reporting facility followed by PORT. PORT was coded as performed at either the same facility or at a different facility as surgery. Results: A total of 10 832 patients were selected. Five-year overall survival (OS) was higher in patients undergoing PORT at the same facility: 52.5% vs 48.4% (P < 0.001). PORT performed at the same facility was associated with improved OS under multivariate (HR, 0.92; P = 0.01) and propensity score matched (hazard ratio, 0.90; P = 0.004) analyses. Conclusions: OS was better among patients with head and neck cancer who received PORT at the same facility as surgery.

Original language	English
Pages (from-to)	2299-2308
Number of pages	10
Journal	Head and Neck
Volume	41
Issue number	7
DOIs	https://doi.org/10.1002/hed.25697
State	Published - Jul 2019

Keywords

facility location
National Cancer Database (NCDB)
oral cavity cancer
outcomes
postoperative radiation therapy (PORT)

Access to Document

10.1002/hed.25697

Cite this

@article{198c17e4e21145f0908d6ad8e3ab3b60,

title = "Postoperative radiation performed at the same surgical facility associated with improved overall survival in oral cavity squamous cell carcinoma",

abstract = "Background: The purpose of this analysis is to evaluate whether postoperative radiotherapy (PORT) at the same facility as surgery portends to better survival outcomes compared to PORT given at a different facility. Methods: Patients underwent upfront surgery at the National Cancer Database reporting facility followed by PORT. PORT was coded as performed at either the same facility or at a different facility as surgery. Results: A total of 10 832 patients were selected. Five-year overall survival (OS) was higher in patients undergoing PORT at the same facility: 52.5% vs 48.4% (P < 0.001). PORT performed at the same facility was associated with improved OS under multivariate (HR, 0.92; P = 0.01) and propensity score matched (hazard ratio, 0.90; P = 0.004) analyses. Conclusions: OS was better among patients with head and neck cancer who received PORT at the same facility as surgery.",

keywords = "facility location, National Cancer Database (NCDB), oral cavity cancer, outcomes, postoperative radiation therapy (PORT)",

author = "Arya Amini and Stokes, {William A.} and Jones, {Bernard L.} and Sagus Sampath and Kang, {Robert S.} and Gernon, {Thomas J.} and Maghami, {Ellie G.} and Erminia Massarelli and Bradley, {Cathy J.} and Karam, {Sana D.}",

note = "Publisher Copyright: {\textcopyright} 2019 Wiley Periodicals, Inc.",

year = "2019",

month = jul,

doi = "10.1002/hed.25697",

language = "English",

volume = "41",

pages = "2299--2308",

journal = "Head and Neck",

issn = "1043-3074",

number = "7",

}

TY - JOUR

T1 - Postoperative radiation performed at the same surgical facility associated with improved overall survival in oral cavity squamous cell carcinoma

AU - Amini, Arya

AU - Stokes, William A.

AU - Jones, Bernard L.

AU - Sampath, Sagus

AU - Kang, Robert S.

AU - Gernon, Thomas J.

AU - Maghami, Ellie G.

AU - Massarelli, Erminia

AU - Bradley, Cathy J.

AU - Karam, Sana D.

PY - 2019/7

Y1 - 2019/7

N2 - Background: The purpose of this analysis is to evaluate whether postoperative radiotherapy (PORT) at the same facility as surgery portends to better survival outcomes compared to PORT given at a different facility. Methods: Patients underwent upfront surgery at the National Cancer Database reporting facility followed by PORT. PORT was coded as performed at either the same facility or at a different facility as surgery. Results: A total of 10 832 patients were selected. Five-year overall survival (OS) was higher in patients undergoing PORT at the same facility: 52.5% vs 48.4% (P < 0.001). PORT performed at the same facility was associated with improved OS under multivariate (HR, 0.92; P = 0.01) and propensity score matched (hazard ratio, 0.90; P = 0.004) analyses. Conclusions: OS was better among patients with head and neck cancer who received PORT at the same facility as surgery.

AB - Background: The purpose of this analysis is to evaluate whether postoperative radiotherapy (PORT) at the same facility as surgery portends to better survival outcomes compared to PORT given at a different facility. Methods: Patients underwent upfront surgery at the National Cancer Database reporting facility followed by PORT. PORT was coded as performed at either the same facility or at a different facility as surgery. Results: A total of 10 832 patients were selected. Five-year overall survival (OS) was higher in patients undergoing PORT at the same facility: 52.5% vs 48.4% (P < 0.001). PORT performed at the same facility was associated with improved OS under multivariate (HR, 0.92; P = 0.01) and propensity score matched (hazard ratio, 0.90; P = 0.004) analyses. Conclusions: OS was better among patients with head and neck cancer who received PORT at the same facility as surgery.

KW - facility location

KW - National Cancer Database (NCDB)

KW - oral cavity cancer

KW - outcomes

KW - postoperative radiation therapy (PORT)

UR - http://www.scopus.com/inward/record.url?scp=85061256837&partnerID=8YFLogxK

U2 - 10.1002/hed.25697

DO - 10.1002/hed.25697

M3 - Article

C2 - 30737961

AN - SCOPUS:85061256837

SN - 1043-3074

VL - 41

SP - 2299

EP - 2308

JO - Head and Neck

JF - Head and Neck

IS - 7

ER -

Postoperative radiation performed at the same surgical facility associated with improved overall survival in oral cavity squamous cell carcinoma

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this