Postnatal weight gain in preterm infants with severe bronchopulmonary dysplasia

Girija Natarajan, Yvette R. Johnson, Beverly Brozanski, Kathryn N. Farrow, Isabella Zaniletti, Michael A. Padula, Jeanette M. Asselin, David J. Durand, Billie L. Short, Eugenia K. Pallotto, Francine D. Dykes, Kristina M. Reber, Jacquelyn R. Evans, Karna Murthy

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34 Scopus citations


Objectives To characterize postnatal growth failure (PGF), defined as weight < 10th percentile for postmenstrual age (PMA) in preterm (≤ 27 weeks' gestation) infants with severe bronchopulmonary dysplasia (sBPD) at specified time points during hospitalization, and to compare these in subgroups of infants who died/underwent tracheostomy and others. Study Design Retrospective review of data from the multicenter Children's Hospital Neonatal Database (CHND). Results Our cohort (n = 375) had a mean ± standard deviation gestation of 25 ± 1.2 weeks and birth weight of 744 ± 196 g. At birth, 20% of infants were small for gestational age (SGA); age at referral to the CHND neonatal intensive care unit (NICU) was 46 ± 50 days. PGF rates at admission and at 36, 40, 44, and 48 weeks' PMA were 33, 53, 67, 66, and 79% of infants, respectively. Tube feedings were administered to > 70% and parenteral nutrition to a third of infants between 36 and 44 weeks' PMA. At discharge, 34% of infants required tube feedings and 50% had PGF. A significantly greater (38 versus 17%) proportion of infants who died/underwent tracheostomy (n = 69) were SGA, compared with those who did not (n = 306; p < 0.01). Conclusions Infants with sBPD commonly had progressive PGF during their NICU hospitalization. Fetal growth restriction may be a marker of adverse outcomes in this population.

Original languageEnglish
Pages (from-to)223-230
Number of pages8
JournalAmerican journal of perinatology
Issue number3
StatePublished - Mar 2014


  • bronchopulmonary dysplasia
  • growth
  • nutrition
  • tracheostomy


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