Postnatal ontogeny of cholecystokinin receptors in rat brain

Sally E. Hays; Sally H. Houston; Margery C. Beinfeld; Steven M. Paul

doi:10.1016/0006-8993(81)91269-5

Postnatal ontogeny of cholecystokinin receptors in rat brain

Sally E. Hays
, Sally H. Houston
, Margery C. Beinfeld
, Steven M. Paul

School of Medicine

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

The postnatal ontogeny of cholecystokinin receptors and cholecystokinin was determined in rat brain. The binding of cholecystokinin (CCK) to rat forebrain receptors was very low at 1-2 days of age, rose to a maximum at 12 days (B_max = 31 fmol/mg protein, K_d = 1.47 nM), and declined to adult levels by 26 days (B_max = 17 fmol/mg protein, K_d = 1.39 nM). In contrast, forebrain concentrations of CCK measured by radioimmunoassay rose monotonically through day 27. Possible implications of the transient developmental peak of CCK receptors are discussed.

Original language	English
Pages (from-to)	237-241
Number of pages	5
Journal	Brain Research
Volume	213
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(81)91269-5
State	Published - May 25 1981

Keywords

brain
cholecystokinin receptor
development

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10.1016/0006-8993(81)91269-5

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title = "Postnatal ontogeny of cholecystokinin receptors in rat brain",

abstract = "The postnatal ontogeny of cholecystokinin receptors and cholecystokinin was determined in rat brain. The binding of cholecystokinin (CCK) to rat forebrain receptors was very low at 1-2 days of age, rose to a maximum at 12 days (Bmax = 31 fmol/mg protein, Kd = 1.47 nM), and declined to adult levels by 26 days (Bmax = 17 fmol/mg protein, Kd = 1.39 nM). In contrast, forebrain concentrations of CCK measured by radioimmunoassay rose monotonically through day 27. Possible implications of the transient developmental peak of CCK receptors are discussed.",

keywords = "brain, cholecystokinin receptor, development",

author = "Hays, \{Sally E.\} and Houston, \{Sally H.\} and Beinfeld, \{Margery C.\} and Paul, \{Steven M.\}",

year = "1981",

month = may,

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doi = "10.1016/0006-8993(81)91269-5",

language = "English",

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T1 - Postnatal ontogeny of cholecystokinin receptors in rat brain

AU - Hays, Sally E.

AU - Houston, Sally H.

AU - Beinfeld, Margery C.

AU - Paul, Steven M.

PY - 1981/5/25

Y1 - 1981/5/25

N2 - The postnatal ontogeny of cholecystokinin receptors and cholecystokinin was determined in rat brain. The binding of cholecystokinin (CCK) to rat forebrain receptors was very low at 1-2 days of age, rose to a maximum at 12 days (Bmax = 31 fmol/mg protein, Kd = 1.47 nM), and declined to adult levels by 26 days (Bmax = 17 fmol/mg protein, Kd = 1.39 nM). In contrast, forebrain concentrations of CCK measured by radioimmunoassay rose monotonically through day 27. Possible implications of the transient developmental peak of CCK receptors are discussed.

AB - The postnatal ontogeny of cholecystokinin receptors and cholecystokinin was determined in rat brain. The binding of cholecystokinin (CCK) to rat forebrain receptors was very low at 1-2 days of age, rose to a maximum at 12 days (Bmax = 31 fmol/mg protein, Kd = 1.47 nM), and declined to adult levels by 26 days (Bmax = 17 fmol/mg protein, Kd = 1.39 nM). In contrast, forebrain concentrations of CCK measured by radioimmunoassay rose monotonically through day 27. Possible implications of the transient developmental peak of CCK receptors are discussed.

KW - brain

KW - cholecystokinin receptor

KW - development

UR - https://www.scopus.com/pages/publications/0019460275

U2 - 10.1016/0006-8993(81)91269-5

DO - 10.1016/0006-8993(81)91269-5

M3 - Article

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AN - SCOPUS:0019460275

SN - 0006-8993

VL - 213

SP - 237

EP - 241

JO - Brain Research

JF - Brain Research

IS - 1

ER -

Postnatal ontogeny of cholecystokinin receptors in rat brain

Abstract

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