Postnatal ontogeny of cholecystokinin receptors in rat brain

Sally E. Hays; Sally H. Houston; Margery C. Beinfeld; Steven M. Paul

doi:10.1016/0006-8993(81)91269-5

Postnatal ontogeny of cholecystokinin receptors in rat brain

Sally E. Hays, Sally H. Houston, Margery C. Beinfeld, Steven M. Paul

Washington University School of Medicine

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The postnatal ontogeny of cholecystokinin receptors and cholecystokinin was determined in rat brain. The binding of cholecystokinin (CCK) to rat forebrain receptors was very low at 1-2 days of age, rose to a maximum at 12 days (B_max = 31 fmol/mg protein, K_d = 1.47 nM), and declined to adult levels by 26 days (B_max = 17 fmol/mg protein, K_d = 1.39 nM). In contrast, forebrain concentrations of CCK measured by radioimmunoassay rose monotonically through day 27. Possible implications of the transient developmental peak of CCK receptors are discussed.

Original language	English
Pages (from-to)	237-241
Number of pages	5
Journal	Brain Research
Volume	213
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(81)91269-5
State	Published - May 25 1981

Keywords

brain
cholecystokinin receptor
development

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10.1016/0006-8993(81)91269-5

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title = "Postnatal ontogeny of cholecystokinin receptors in rat brain",

abstract = "The postnatal ontogeny of cholecystokinin receptors and cholecystokinin was determined in rat brain. The binding of cholecystokinin (CCK) to rat forebrain receptors was very low at 1-2 days of age, rose to a maximum at 12 days (Bmax = 31 fmol/mg protein, Kd = 1.47 nM), and declined to adult levels by 26 days (Bmax = 17 fmol/mg protein, Kd = 1.39 nM). In contrast, forebrain concentrations of CCK measured by radioimmunoassay rose monotonically through day 27. Possible implications of the transient developmental peak of CCK receptors are discussed.",

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AU - Hays, Sally E.

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AU - Beinfeld, Margery C.

AU - Paul, Steven M.

PY - 1981/5/25

Y1 - 1981/5/25

N2 - The postnatal ontogeny of cholecystokinin receptors and cholecystokinin was determined in rat brain. The binding of cholecystokinin (CCK) to rat forebrain receptors was very low at 1-2 days of age, rose to a maximum at 12 days (Bmax = 31 fmol/mg protein, Kd = 1.47 nM), and declined to adult levels by 26 days (Bmax = 17 fmol/mg protein, Kd = 1.39 nM). In contrast, forebrain concentrations of CCK measured by radioimmunoassay rose monotonically through day 27. Possible implications of the transient developmental peak of CCK receptors are discussed.

AB - The postnatal ontogeny of cholecystokinin receptors and cholecystokinin was determined in rat brain. The binding of cholecystokinin (CCK) to rat forebrain receptors was very low at 1-2 days of age, rose to a maximum at 12 days (Bmax = 31 fmol/mg protein, Kd = 1.47 nM), and declined to adult levels by 26 days (Bmax = 17 fmol/mg protein, Kd = 1.39 nM). In contrast, forebrain concentrations of CCK measured by radioimmunoassay rose monotonically through day 27. Possible implications of the transient developmental peak of CCK receptors are discussed.

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Postnatal ontogeny of cholecystokinin receptors in rat brain

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