Postnatal ontogeny of cholecystokinin receptors in rat brain

Sally E. Hays, Sally H. Houston, Margery C. Beinfeld, Steven M. Paul

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The postnatal ontogeny of cholecystokinin receptors and cholecystokinin was determined in rat brain. The binding of cholecystokinin (CCK) to rat forebrain receptors was very low at 1-2 days of age, rose to a maximum at 12 days (Bmax = 31 fmol/mg protein, Kd = 1.47 nM), and declined to adult levels by 26 days (Bmax = 17 fmol/mg protein, Kd = 1.39 nM). In contrast, forebrain concentrations of CCK measured by radioimmunoassay rose monotonically through day 27. Possible implications of the transient developmental peak of CCK receptors are discussed.

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalBrain Research
Issue number1
StatePublished - May 25 1981


  • brain
  • cholecystokinin receptor
  • development


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