TY - JOUR
T1 - Postmenopausal osteoporosis. A heterogeneous disorder as assessed by histomorphometric analysis of iliac crest bone from untreated patients
AU - Whyte, Michael P.
AU - Bergfeld, Michele A.
AU - Murphy, William A.
AU - Avioli, Louis V.
AU - Teitelbaum, Steven L.
PY - 1982/2
Y1 - 1982/2
N2 - Twenty-six women with untreated postmenopausal osteoporosis underwent iliac crest biopsy following tetracycline-labeling and mineral metabolism studies. Histomorphometric assessment of their bone remodeling rates, including formation determined by the tetracycline-labeling technique, revealed considerable variation. Eight women had no evidence of active bone formation (inactive remodeling osteoporosis), whereas the others showed a spectrum of bone formation rates (active remodeling osteoporosis). Clinical and biochemical studies failed to predict the histomorphometric findings. Postmenopausal osteoporosis is a histologically heterogeneous disorder with morphologic expression in bone that cannot be predicted by single or combined routine clinical and laboratory parameters. Bone biopsy, necessary to identify the histologic lesion and assess skeletal dynamics, may prove to be important for optimal therapy of osteoporosis, as a variety of agents-with different effects on bone remodeling-are available.
AB - Twenty-six women with untreated postmenopausal osteoporosis underwent iliac crest biopsy following tetracycline-labeling and mineral metabolism studies. Histomorphometric assessment of their bone remodeling rates, including formation determined by the tetracycline-labeling technique, revealed considerable variation. Eight women had no evidence of active bone formation (inactive remodeling osteoporosis), whereas the others showed a spectrum of bone formation rates (active remodeling osteoporosis). Clinical and biochemical studies failed to predict the histomorphometric findings. Postmenopausal osteoporosis is a histologically heterogeneous disorder with morphologic expression in bone that cannot be predicted by single or combined routine clinical and laboratory parameters. Bone biopsy, necessary to identify the histologic lesion and assess skeletal dynamics, may prove to be important for optimal therapy of osteoporosis, as a variety of agents-with different effects on bone remodeling-are available.
UR - http://www.scopus.com/inward/record.url?scp=0020045658&partnerID=8YFLogxK
U2 - 10.1016/0002-9343(82)90810-5
DO - 10.1016/0002-9343(82)90810-5
M3 - Article
C2 - 7058831
AN - SCOPUS:0020045658
SN - 0002-9343
VL - 72
SP - 193
EP - 202
JO - The American journal of medicine
JF - The American journal of medicine
IS - 2
ER -