Posterior reversible encephalopathy syndrome associated with Guillain-Barré syndrome: Case report and clinical management considerations

Alessandro Salvalaggio, Annachiara Cagnin, Piero Marson, Franco Ferracci, Pietro Cortelli, Maurizio Corbetta, Chiara Briani

Research output: Contribution to journalArticlepeer-review

Abstract

Around half of the patients with Guillain-Barré syndrome (GBS) present autonomic dysfunction requiring admission to intensive care unit in up to a quarter of patients. Treatment of GBS consists of plasma exchange (PE) and intravenous immunoglobulins (IVIG). Posterior reversible encephalopathy syndrome (PRES) consists in a reversible subcortical vasogenic brain edema caused by endothelial damage triggered by abrupt blood pressure changes. We report on a woman who presented with PRES in the course of GBS treated first with IVIG, and then with PE. The present report underlines the challenge that the clinicians face when these two rare syndromes concur. The literature is not helpful considering that both blood pressure fluctuations and IVIG are reported to be involved in the pathogenesis of PRES. In the present letter, both pathogenic mechanisms and clinical management considerations are discussed.

Original languageEnglish
Pages (from-to)231-233
Number of pages3
JournalJournal of Clinical Apheresis
Volume35
Issue number3
DOIs
StatePublished - Jun 1 2020
Externally publishedYes

Keywords

  • dysautonomia
  • Guillain-Barré syndrome
  • intravenous immunoglobulins
  • plasma exchange
  • posterior reversible encephalopathy syndrome

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