@inbook{8d2be6f7aa9649b4a3189567d1250ef7,
title = "Positron Emission Tomography (PET) for Molecular Plant Imaging",
abstract = "Positron emission tomography (PET) is an imaging technology that measures 3D spatial distribution and kinetics of radio-tagged biomolecules in a living subject quantitatively and nondestructively. Commonly used positron-emitting radionuclides include11C,13N, and15O, which are essential elements for plant growth. Combining radiotracer techniques with PET, this in vivo molecular imaging capability offers plant biologists a powerful tool for molecular phenotyping research. While PET is widely used clinically for cancer diagnosis and pre-clinically for drug development, it is an unfamiliar imaging tool for plant biologists. This chapter introduces the basic principles of PET, factors that affect the quantitative accuracy of PET when imaging plants, and techniques for administering radiotracers to plants for a variety of molecular plant imaging applications.",
keywords = "Molecular imaging, PET, Plant phenotyping, Positron emission tomography",
author = "Sergey Komarov and Tai, {Yuan Chuan}",
note = "Funding Information: This work was supported in part by the US National Science Foundation (NSF DBI-1040498 and EPSCoR IIA 1430427/IIA 1430428), US Department of Energy (DOE-BER, DE-SC0005157), National Academies Keck Futures Initiative, Washington University in St. Louis I-CARES program, and Mal-linckrodt Institute of Radiology. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2022",
doi = "10.1007/978-1-0716-2537-8_11",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "97--118",
booktitle = "Methods in Molecular Biology",
}