Positron emission tomography measurements of pulmonary vascular permeability with Ga-68 transferrin or C-11 methylalbumin

Daniel P. Schuster, Joanne Markham, Michael J. Welch

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Objective: To compare estimates of pulmonary endothelial barrier integrity obtained using two different tracer proteins. Design: Measure the pulmonary transcapillary escape rate with gallium (Ga)-68 labeled transferrin (PTCER(d)) and positron emission tomography (PET) imaging and compare the results to similar measurements obtained with C-11 labeled methylalbumin (PTCER(alb)). Setting: Laboratory investigation. Subjects: Mongrel dogs. Interventions: No intervention in one group of dogs (n = 3); oleic-acid induced lung injury in another set (n = 4). Measurements and Main Results: Although PTCER(ti) was consistently higher than PTCER(alb) (mean difference: 50 x 10-4/min), the overall correlation between the two methods, after normalizing for differences in regression slope and intercept among the individual dogs, was excellent (r2 = .67). Conclusion: The data support the continued use of PET and Ga-68 transferrin as an appropriate means of evaluating and quantifying lung injury.

Original languageEnglish
Pages (from-to)518-525
Number of pages8
JournalCritical care medicine
Volume26
Issue number3
DOIs
StatePublished - Apr 8 1998

Keywords

  • Acute lung injury
  • Barrier function
  • Dogs
  • Endothelium
  • Imaging
  • Positron emission tomography

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