Positional requirements for the stimulation of mRNA nuclear export by ALREX-promoting elements

Stefan P. Tarnawsky; Alexander F. Palazzo

doi:10.1039/c2mb25016k

Positional requirements for the stimulation of mRNA nuclear export by ALREX-promoting elements

Stefan P. Tarnawsky
, Alexander F. Palazzo

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The majority of vertebrate mRNAs that encode secreted, membrane-bound or mitochondrial proteins contain elements at the 5′ end of the ORF that activate an alternative mRNA nuclear export (ALREX) pathway. Here we demonstrate that these elements promote efficient export and proper cytoplasmic localization only when they are found at the 5′ end of the transcript.

Original language	English
Pages (from-to)	2527-2530
Number of pages	4
Journal	Molecular BioSystems
Volume	8
Issue number	10
DOIs	https://doi.org/10.1039/c2mb25016k
State	Published - Oct 2012

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abstract = "The majority of vertebrate mRNAs that encode secreted, membrane-bound or mitochondrial proteins contain elements at the 5′ end of the ORF that activate an alternative mRNA nuclear export (ALREX) pathway. Here we demonstrate that these elements promote efficient export and proper cytoplasmic localization only when they are found at the 5′ end of the transcript.",

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AB - The majority of vertebrate mRNAs that encode secreted, membrane-bound or mitochondrial proteins contain elements at the 5′ end of the ORF that activate an alternative mRNA nuclear export (ALREX) pathway. Here we demonstrate that these elements promote efficient export and proper cytoplasmic localization only when they are found at the 5′ end of the transcript.

UR - https://www.scopus.com/pages/publications/84865803629

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DO - 10.1039/c2mb25016k

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Positional requirements for the stimulation of mRNA nuclear export by ALREX-promoting elements

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