Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells

Patrícia M.R. Pereira, José J. Carvalho, Sandrina Silva, José A.S. Cavaleiro, Rudolf J. Schneider, Rosa Fernandes, João P.C. Tomé

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

The synthesis of a novel PS conjugated with bovine and human serum albumin (BSA and HSA) and a monoclonal antibody anti-CD104 is reported, as well as their biological potential against the human bladder cancer cell line UM-UC-3. No photodynamic effect was detected when the non-conjugated porphyrin was used. Yet, when it was coupled covalently with the mAb anti-CD104, BSA and HSA, the resulting photosensitizer conjugates demonstrated high efficacy in destroying the cancer cells, the mAb anti-CD104 efficacy overruling the albumins.

Original languageEnglish
Pages (from-to)1804-1811
Number of pages8
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number11
DOIs
StatePublished - Mar 21 2014

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