TY - JOUR
T1 - Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells
AU - Pereira, Patrícia M.R.
AU - Carvalho, José J.
AU - Silva, Sandrina
AU - Cavaleiro, José A.S.
AU - Schneider, Rudolf J.
AU - Fernandes, Rosa
AU - Tomé, João P.C.
PY - 2014/3/21
Y1 - 2014/3/21
N2 - The synthesis of a novel PS conjugated with bovine and human serum albumin (BSA and HSA) and a monoclonal antibody anti-CD104 is reported, as well as their biological potential against the human bladder cancer cell line UM-UC-3. No photodynamic effect was detected when the non-conjugated porphyrin was used. Yet, when it was coupled covalently with the mAb anti-CD104, BSA and HSA, the resulting photosensitizer conjugates demonstrated high efficacy in destroying the cancer cells, the mAb anti-CD104 efficacy overruling the albumins.
AB - The synthesis of a novel PS conjugated with bovine and human serum albumin (BSA and HSA) and a monoclonal antibody anti-CD104 is reported, as well as their biological potential against the human bladder cancer cell line UM-UC-3. No photodynamic effect was detected when the non-conjugated porphyrin was used. Yet, when it was coupled covalently with the mAb anti-CD104, BSA and HSA, the resulting photosensitizer conjugates demonstrated high efficacy in destroying the cancer cells, the mAb anti-CD104 efficacy overruling the albumins.
UR - http://www.scopus.com/inward/record.url?scp=84894412239&partnerID=8YFLogxK
U2 - 10.1039/c3ob42082e
DO - 10.1039/c3ob42082e
M3 - Article
C2 - 24513883
AN - SCOPUS:84894412239
SN - 1477-0520
VL - 12
SP - 1804
EP - 1811
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 11
ER -