Porous biodegradable polymer scaffolds were manufactured and characterized for nerve regeneration. A biodegradable polymer consisting of 75:25 PLGA was dissolved in methylene chloride and salt crystals. The mixture was heated and then extruded to form tubes. Mechanical testing was performed by embedding conduits into aluminum tubes. In vitro study was performed to determine the influence of degradation on mechanical properties. In vivo study was carried out by interposing conduits into the right sciatic nerve of rats. After 6 six, the conduits were removed for histology. The stress versus strain plot from mechanical testing revealed an initial linear region. However, after applying a certain level of force, the stress rapidly deviated. Histology tests showed that after 6 weeks, all conduits remained flexible and there was no severe inflammatory reaction.
|Number of pages||2|
|State||Published - Jan 1 1997|
|Event||Proceedings of the 1997 Bioengineering Conference - Sunriver, OR, USA|
Duration: Jun 11 1997 → Jun 15 1997
|Conference||Proceedings of the 1997 Bioengineering Conference|
|City||Sunriver, OR, USA|
|Period||06/11/97 → 06/15/97|