Pore formation in phospholipid bilayers by branched-chain pyrogallol[4]arenes

  • Saeedeh Negin
  • , Megan M. Daschbach
  • , Oleg V. Kulikov
  • , Nigam Rath
  • , George W. Gokel

Research output: Contribution to journalArticlepeer-review

48 Scopus citations

Abstract

Pyrogallolarenes are tetrameric macrocycles that form from 1,2,3-trihydroxybenzene and aldehydes under acidic conditions. When 2-ethylbutanal or 2-propylpentanal was so treated, the branched-chain pyrogallolarenes crystallized as nanotubes or bilayers, respectively. When the behavior of each compound was assessed by using the planar bilayer conductance method, pore formation was observed. The properties of the pores were significantly different from each other, probably reflecting different types of pore organization within the membrane.

Original languageEnglish
Pages (from-to)3234-3237
Number of pages4
JournalJournal of the American Chemical Society
Volume133
Issue number10
DOIs
StatePublished - Mar 16 2011

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