Pore formation in and enlargement of phospholipid liposomes by synthetic models of ceramides and sphingomyelin

Robert Pajewski; Natasha Djedovič; Egan Harder; Riccardo Ferdani; Paul H. Schlesinger; George W. Gokel

doi:10.1016/j.bmc.2004.10.001

Pore formation in and enlargement of phospholipid liposomes by synthetic models of ceramides and sphingomyelin

Robert Pajewski
, Natasha Djedovič
, Egan Harder
, Riccardo Ferdani
, Paul H. Schlesinger
, George W. Gokel

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A family of compounds having twin octadecyl anchor chains and various polar headgroups were designed to be ceramide mimics. The compounds prepared increase the apparent permeability of phospholipid vesicles to chloride and carboxyfluorescein anions. In addition, significantly larger vesicles are observed after exposure to these compounds suggesting the possibility of vesicular fusion.

Original language	English
Pages (from-to)	29-37
Number of pages	9
Journal	Bioorganic and Medicinal Chemistry
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/j.bmc.2004.10.001
State	Published - Jan 3 2005

Keywords

Aggregation
Ceramide
Ion channel

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10.1016/j.bmc.2004.10.001

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title = "Pore formation in and enlargement of phospholipid liposomes by synthetic models of ceramides and sphingomyelin",

abstract = "A family of compounds having twin octadecyl anchor chains and various polar headgroups were designed to be ceramide mimics. The compounds prepared increase the apparent permeability of phospholipid vesicles to chloride and carboxyfluorescein anions. In addition, significantly larger vesicles are observed after exposure to these compounds suggesting the possibility of vesicular fusion.",

keywords = "Aggregation, Ceramide, Ion channel",

author = "Robert Pajewski and Natasha Djedovi{\v c} and Egan Harder and Riccardo Ferdani and Schlesinger, \{Paul H.\} and Gokel, \{George W.\}",

note = "Funding Information: We thank the NIH for a grant (GM-63190) that supported this work.",

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doi = "10.1016/j.bmc.2004.10.001",

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T1 - Pore formation in and enlargement of phospholipid liposomes by synthetic models of ceramides and sphingomyelin

AU - Pajewski, Robert

AU - Djedovič, Natasha

AU - Harder, Egan

AU - Ferdani, Riccardo

AU - Schlesinger, Paul H.

AU - Gokel, George W.

N1 - Funding Information: We thank the NIH for a grant (GM-63190) that supported this work.

PY - 2005/1/3

Y1 - 2005/1/3

N2 - A family of compounds having twin octadecyl anchor chains and various polar headgroups were designed to be ceramide mimics. The compounds prepared increase the apparent permeability of phospholipid vesicles to chloride and carboxyfluorescein anions. In addition, significantly larger vesicles are observed after exposure to these compounds suggesting the possibility of vesicular fusion.

AB - A family of compounds having twin octadecyl anchor chains and various polar headgroups were designed to be ceramide mimics. The compounds prepared increase the apparent permeability of phospholipid vesicles to chloride and carboxyfluorescein anions. In addition, significantly larger vesicles are observed after exposure to these compounds suggesting the possibility of vesicular fusion.

KW - Aggregation

KW - Ceramide

KW - Ion channel

UR - https://www.scopus.com/pages/publications/9644279588

U2 - 10.1016/j.bmc.2004.10.001

DO - 10.1016/j.bmc.2004.10.001

M3 - Article

C2 - 15582449

AN - SCOPUS:9644279588

SN - 0968-0896

VL - 13

SP - 29

EP - 37

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 1

ER -

Pore formation in and enlargement of phospholipid liposomes by synthetic models of ceramides and sphingomyelin

Abstract

Keywords

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