Pore formation in and enlargement of phospholipid liposomes by synthetic models of ceramides and sphingomyelin

Robert Pajewski, Natasha Djedovič, Egan Harder, Riccardo Ferdani, Paul H. Schlesinger, George W. Gokel

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

A family of compounds having twin octadecyl anchor chains and various polar headgroups were designed to be ceramide mimics. The compounds prepared increase the apparent permeability of phospholipid vesicles to chloride and carboxyfluorescein anions. In addition, significantly larger vesicles are observed after exposure to these compounds suggesting the possibility of vesicular fusion.

Original languageEnglish
Pages (from-to)29-37
Number of pages9
JournalBioorganic and Medicinal Chemistry
Volume13
Issue number1
DOIs
StatePublished - Jan 3 2005

Keywords

  • Aggregation
  • Ceramide
  • Ion channel

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