Porcine models of experimental fulminant hepatic failure

V. Ramachandran; T. D. Whitehead; A. Uliyargoli; J. A. Lowell; S. Shenoy; T. Mohanakumar; T. K. Howard

doi:10.1097/00002480-200003000-00320

Porcine models of experimental fulminant hepatic failure

V. Ramachandran, T. D. Whitehead, A. Uliyargoli, J. A. Lowell, S. Shenoy, T. Mohanakumar, T. K. Howard

Research output: Contribution to journal › Conference article › peer-review

Abstract

In this study, an attempt was made to evaluate two models of chemically induced fulminant hepatic failure (FHF) in pigs: acetaminophen (Ac); and d D-galactosamine (dGal). In Model I, five animals were pretreated with buthionine sulfoximine before dosing them with Ac over a 12 hr period. In Model 2, six animals received a single dose of dGal. The animals were followed clinically and biochemically with serial prothrombin time (PT), serum ammonia (NH3) and transaminase levels (TA) for evidence of liver failure. Pigs given a single dose of dGal formed an excellent model of FHF.

Original language	English
Number of pages	1
Journal	ASAIO Journal
Volume	46
Issue number	2
DOIs	https://doi.org/10.1097/00002480-200003000-00320
State	Published - Jan 1 2000
Event	46th Annual Conference and Exposition of ASAIO - New York, NY, USA Duration: Jun 28 2000 → Jul 1 2000

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title = "Porcine models of experimental fulminant hepatic failure",

abstract = "In this study, an attempt was made to evaluate two models of chemically induced fulminant hepatic failure (FHF) in pigs: acetaminophen (Ac); and d D-galactosamine (dGal). In Model I, five animals were pretreated with buthionine sulfoximine before dosing them with Ac over a 12 hr period. In Model 2, six animals received a single dose of dGal. The animals were followed clinically and biochemically with serial prothrombin time (PT), serum ammonia (NH3) and transaminase levels (TA) for evidence of liver failure. Pigs given a single dose of dGal formed an excellent model of FHF.",

author = "V. Ramachandran and Whitehead, {T. D.} and A. Uliyargoli and Lowell, {J. A.} and S. Shenoy and T. Mohanakumar and Howard, {T. K.}",

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TY - JOUR

T1 - Porcine models of experimental fulminant hepatic failure

AU - Ramachandran, V.

AU - Whitehead, T. D.

AU - Uliyargoli, A.

AU - Lowell, J. A.

AU - Shenoy, S.

AU - Mohanakumar, T.

AU - Howard, T. K.

PY - 2000/1/1

Y1 - 2000/1/1

N2 - In this study, an attempt was made to evaluate two models of chemically induced fulminant hepatic failure (FHF) in pigs: acetaminophen (Ac); and d D-galactosamine (dGal). In Model I, five animals were pretreated with buthionine sulfoximine before dosing them with Ac over a 12 hr period. In Model 2, six animals received a single dose of dGal. The animals were followed clinically and biochemically with serial prothrombin time (PT), serum ammonia (NH3) and transaminase levels (TA) for evidence of liver failure. Pigs given a single dose of dGal formed an excellent model of FHF.

AB - In this study, an attempt was made to evaluate two models of chemically induced fulminant hepatic failure (FHF) in pigs: acetaminophen (Ac); and d D-galactosamine (dGal). In Model I, five animals were pretreated with buthionine sulfoximine before dosing them with Ac over a 12 hr period. In Model 2, six animals received a single dose of dGal. The animals were followed clinically and biochemically with serial prothrombin time (PT), serum ammonia (NH3) and transaminase levels (TA) for evidence of liver failure. Pigs given a single dose of dGal formed an excellent model of FHF.

UR - http://www.scopus.com/inward/record.url?scp=0034159479&partnerID=8YFLogxK

U2 - 10.1097/00002480-200003000-00320

DO - 10.1097/00002480-200003000-00320

M3 - Conference article

AN - SCOPUS:0034159479

VL - 46

JO - ASAIO Journal

JF - ASAIO Journal

SN - 1058-2916

IS - 2

Y2 - 28 June 2000 through 1 July 2000

ER -

Porcine models of experimental fulminant hepatic failure

Abstract

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