Porcine models of experimental fulminant hepatic failure

V. Ramachandran, T. D. Whitehead, A. Uliyargoli, J. A. Lowell, S. Shenoy, T. Mohanakumar, T. K. Howard

Research output: Contribution to journalConference articlepeer-review

Abstract

In this study, an attempt was made to evaluate two models of chemically induced fulminant hepatic failure (FHF) in pigs: acetaminophen (Ac); and d D-galactosamine (dGal). In Model I, five animals were pretreated with buthionine sulfoximine before dosing them with Ac over a 12 hr period. In Model 2, six animals received a single dose of dGal. The animals were followed clinically and biochemically with serial prothrombin time (PT), serum ammonia (NH3) and transaminase levels (TA) for evidence of liver failure. Pigs given a single dose of dGal formed an excellent model of FHF.

Original languageEnglish
Number of pages1
JournalASAIO Journal
Volume46
Issue number2
DOIs
StatePublished - Jan 1 2000
Event46th Annual Conference and Exposition of ASAIO - New York, NY, USA
Duration: Jun 28 2000Jul 1 2000

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