Abstract
In this study, an attempt was made to evaluate two models of chemically induced fulminant hepatic failure (FHF) in pigs: acetaminophen (Ac); and d D-galactosamine (dGal). In Model I, five animals were pretreated with buthionine sulfoximine before dosing them with Ac over a 12 hr period. In Model 2, six animals received a single dose of dGal. The animals were followed clinically and biochemically with serial prothrombin time (PT), serum ammonia (NH3) and transaminase levels (TA) for evidence of liver failure. Pigs given a single dose of dGal formed an excellent model of FHF.
Original language | English |
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Pages (from-to) | 231 |
Number of pages | 1 |
Journal | ASAIO Journal |
Volume | 46 |
Issue number | 2 |
DOIs | |
State | Published - 2000 |
Event | 46th Annual Conference and Exposition of ASAIO - New York, NY, USA Duration: Jun 28 2000 → Jul 1 2000 |