Pomegranate polyphenols and resveratrol protect the neonatal brain against hypoxic-ischemic injury

Tim West, Madeliene Atzeva, David M. Holtzman

Research output: Contribution to journalArticlepeer-review

138 Scopus citations

Abstract

A previous study from our lab has shown that the polyphenol-rich pomegranate juice can protect the neonatal mouse brain against hypoxic-ischemic (H-I) injury when given to mothers in their drinking water. To test the hypothesis that this protection is due to the polyphenols in the juice, we studied the effects of the pomegranate polyphenol extract in the same neonatal H-I model. To further explore the role of a specific polyphenol in neonatal H-I we investigated the effects of resveratrol. The neuroprotective effects of resveratrol have been demonstrated in adult models of stroke, but had not previously been examined in neonates. We show that pomegranate polyphenols and resveratrol reduce caspase-3 activation following neonatal H-I. Resveratrol reduced caspase-3 activation when given before the injury but not when given 3 h after the injury. In addition to preventing caspase-3 activation, resveratrol also reduced calpain activation. Finally, we show that resveratrol can protect against tissue loss measured at 7 days after the injury. These and other recent findings suggest that polyphenols should be further investigated as a potential treatment to decrease brain injury due to neonatal H-I.

Original languageEnglish
Pages (from-to)363-372
Number of pages10
JournalDevelopmental Neuroscience
Volume29
Issue number4-5
DOIs
StatePublished - Aug 2007

Keywords

  • Caspase 3 activation
  • Hypoxic-ischemic injury
  • Polyphenols
  • Pomegranate juice
  • Resveratrol

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