Polyvalent carbocyanine molecular beacons for molecular recognitions

Yunpeng Ye, Sharon Bloch, Samuel Achilefu

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Polyvalent carboxylate-terminating near-infrared (NIR) carbocyanine molecular beacons were prepared by homologation of reactive carboxyl groups of the beacon with imino diacetic acid. Their conjugation with unprotected d-(+)-glucosamine gave dendritic arrays of the carbohydrate on an inner NIR chromophore core. In vivo evaluation of the dendritic glucosamine constructs shows enhanced uptake in proliferating tumor cells relative to surrounding normal tissue. The structural framework of these polyvalent beacons permits the amplification by synergistic effects of a variety of bioactive motifs or chemical sensors in molecular recognition interactions without dramatic change of their desirable NIR spectral properties.

Original languageEnglish
Pages (from-to)7740-7741
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number25
DOIs
StatePublished - Jun 30 2004

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