TY - JOUR
T1 - Polyphosphoester-based cationic nanoparticles serendipitously release integral biologically-active components to serve as novel degradable inducible nitric oxide synthase inhibitors
AU - Shen, Yuefei
AU - Zhang, Shiyi
AU - Zhang, Fuwu
AU - Loftis, Alexander
AU - Pavía-Sanders, Adriana
AU - Zou, Jiong
AU - Fan, Jingwei
AU - Taylor, John Stephen A.
AU - Wooley, Karen L.
PY - 2013/10/18
Y1 - 2013/10/18
N2 - A degradable polyphosphoester (PPE)-based cationic nanoparticle (cSCK), which is integrated constructed as a novel degradable drug device, demonstrates surprisingly efficient inhibition of inducible nitric oxide synthase (iNOS) transcription, and eventually inhibits nitric oxide (NO) over-production, without loading of any specific therapeutic drugs. This system may serve as a promising anti-inflammatory agent toward the treatment of acute lung injury.
AB - A degradable polyphosphoester (PPE)-based cationic nanoparticle (cSCK), which is integrated constructed as a novel degradable drug device, demonstrates surprisingly efficient inhibition of inducible nitric oxide synthase (iNOS) transcription, and eventually inhibits nitric oxide (NO) over-production, without loading of any specific therapeutic drugs. This system may serve as a promising anti-inflammatory agent toward the treatment of acute lung injury.
KW - degradation
KW - iNOS inhibition
KW - integrated construction
KW - polyphosphoester-based nanoparticle
UR - https://www.scopus.com/pages/publications/84886313865
U2 - 10.1002/adma.201302842
DO - 10.1002/adma.201302842
M3 - Article
C2 - 23999874
AN - SCOPUS:84886313865
SN - 0935-9648
VL - 25
SP - 5609
EP - 5614
JO - Advanced Materials
JF - Advanced Materials
IS - 39
ER -