Polypeptide multilayer films

Donald T. Haynie, Ling Zhang, Jai S. Rudra, Wanhua Zhao, Yang Zhong, Naveen Palath

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations


Research on polypeptide multilayer films, coatings, and microcapsules is located at the intersection of several disciplines: synthetic polymer chemistry and physics, biomaterials science, and nanoscale engineering. The past few years have witnessed considerable growth in each of these areas. Unxplored territory has been found at the borders, and new possibilities for technology development are taking form from technological advances in polypeptide production, sequencing of the human genome, and the nature of peptides themselves. Most envisioned applications of polypeptide multilayers have a biomedical bent. Prospects seem no less positive, however, in fields ranging from food technology to environmental science. This review of the present state of polypeptide multilayer film research covers key points of polypeptides as materials, means of polymer production and film preparation, film characterization methods, focal points of current research in basic science, and the outlook for a few specific applications. In addition, it discusses how the study of polypeptide multilayer films could help to clarify the physical basis of assembly and stability of polyelectrolyte multilayers, and mention is made of similarities to protein folding studies.

Original languageEnglish
Pages (from-to)2895-2913
Number of pages19
Issue number6
StatePublished - Nov 2005


Dive into the research topics of 'Polypeptide multilayer films'. Together they form a unique fingerprint.

Cite this