TY - JOUR
T1 - Polymorphisms in the GNB3 and ADD1 genes and blood pressure in a Chinese population
AU - Chen, Shufeng
AU - Wang, Hongwei
AU - Lu, Xiangfeng
AU - Liu, De Pei
AU - Chen, Jing
AU - Jaquish, Cashell E.
AU - Rao, Dabeeru C.
AU - Hixson, James E.
AU - Kelly, Tanika N.
AU - Hou, Liping
AU - Wang, Laiyuan
AU - Huang, Jianfeng
AU - Chen, Chung Shiuan
AU - Rice, Treva K.
AU - Whelton, Paul K.
AU - He, Jiang
AU - Gu, Dongfeng
N1 - Funding Information:
Acknowledgments The Genetic Epidemiology Network of Salt Sensitivity (GenSalt) is supported by a cooperative agreement project Grant (U01HL072507) from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.
PY - 2010/8
Y1 - 2010/8
N2 - A large proportion of the phenotypic variation in blood pressure (BP) appears to be inherited as a polygenic trait. This study examined the association between 12 single nucleotide polymorphisms (SNPs) in the guanine nucleotide binding protein beta polypeptide 3 (GNB3) and adducin 1 alpha (ADD1) genes and systolic (SBP), diastolic (DBP), and mean arterial (MAP) BP. A total of 3,142 individuals from 636 families were recruited from rural north China, and 2,746 met the eligibility criteria for analysis. BP measurements were obtained using a random-zero sphygmomanometer. Genetic variants were determined using SNPlex assays on an automated DNA Sequencer. A mixed linear model was used to estimate the association between each SNP and BP level. After Bonferroni correction, marker rs4963516 of the GNB3 gene remained significantly associated with DBP (corrected P values = 0.006, 0.007 and 0.002 for co-dominant, additive, and recessive models, respectively) and MAP (corrected P values = 0.02, 0.049, and 0.005, respectively). Compared to carriers of the major A allele, CC homozygotes had higher mean DBP (75.81 ± 0.62 vs. 73.46 ± 0.25 mmHg, P = 0.0002) and MAP (91.87 ± 0.68 vs. 89.42 ± 0.28 mmHg, P = 0.0004) after adjusting for covariates of age, gender, BMI, study site, and room temperature during BP measurement. In summary, these data support a role for the GNB3 gene in BP regulation in the Chinese population. Future studies aimed at replicating these novel findings are warranted.
AB - A large proportion of the phenotypic variation in blood pressure (BP) appears to be inherited as a polygenic trait. This study examined the association between 12 single nucleotide polymorphisms (SNPs) in the guanine nucleotide binding protein beta polypeptide 3 (GNB3) and adducin 1 alpha (ADD1) genes and systolic (SBP), diastolic (DBP), and mean arterial (MAP) BP. A total of 3,142 individuals from 636 families were recruited from rural north China, and 2,746 met the eligibility criteria for analysis. BP measurements were obtained using a random-zero sphygmomanometer. Genetic variants were determined using SNPlex assays on an automated DNA Sequencer. A mixed linear model was used to estimate the association between each SNP and BP level. After Bonferroni correction, marker rs4963516 of the GNB3 gene remained significantly associated with DBP (corrected P values = 0.006, 0.007 and 0.002 for co-dominant, additive, and recessive models, respectively) and MAP (corrected P values = 0.02, 0.049, and 0.005, respectively). Compared to carriers of the major A allele, CC homozygotes had higher mean DBP (75.81 ± 0.62 vs. 73.46 ± 0.25 mmHg, P = 0.0002) and MAP (91.87 ± 0.68 vs. 89.42 ± 0.28 mmHg, P = 0.0004) after adjusting for covariates of age, gender, BMI, study site, and room temperature during BP measurement. In summary, these data support a role for the GNB3 gene in BP regulation in the Chinese population. Future studies aimed at replicating these novel findings are warranted.
UR - https://www.scopus.com/pages/publications/77955284230
U2 - 10.1007/s00439-010-0834-3
DO - 10.1007/s00439-010-0834-3
M3 - Article
C2 - 20473689
AN - SCOPUS:77955284230
SN - 0340-6717
VL - 128
SP - 137
EP - 143
JO - Human genetics
JF - Human genetics
IS - 2
ER -